Neurophysiological recording of the compound muscle action potential for motor unit number estimation in mice

Ngo, Shyuan T. and Bellingham, Mark C. (2013). Neurophysiological recording of the compound muscle action potential for motor unit number estimation in mice. In Pilowsky, Paul M., Farnham, Melissa M. J. and Fong, Angelina Y. (Ed.), Stimulation and inhibition of neurons (pp. 225-235) New York, NY, United States: Humana Press. doi:10.1007/978-1-62703-233-9_13


Author Ngo, Shyuan T.
Bellingham, Mark C.
Title of chapter Neurophysiological recording of the compound muscle action potential for motor unit number estimation in mice
Title of book Stimulation and inhibition of neurons
Place of Publication New York, NY, United States
Publisher Humana Press
Publication Year 2013
Sub-type Chapter in textbook
DOI 10.1007/978-1-62703-233-9_13
Series Neuromethods
ISBN 9781627032322
9781627032339
ISSN 0893-2336
1940-6045
Editor Pilowsky, Paul M.
Farnham, Melissa M. J.
Fong, Angelina Y.
Chapter number 13
Start page 225
End page 235
Total pages 11
Total chapters 18
Collection year 2014
Language eng
Abstract/Summary Motor unit number estimation (MUNE) techniques estimate the number of motor units innervating a single muscle or a group of muscles. As such, MUNE techniques are commonly used to quantify the loss of motor units in disease. MUNE requires obtaining and analysing neurophysiological recordings of compound muscle action potentials (CMAPs) evoked by stimulation of a peripheral nerve. Here, we describe a neurophysiological method that allows for the generation of stimulus–response curves that are achieved through increasing incremental electrical stimulation of the right sciatic nerve of mice and recording of the CMAP in the right gastrocnemius muscle. Performing this neurophysiological technique for subsequent MUNE analysis has vast implications for determining motor unit numbers where motor unit loss is thought to occur.
Keyword Neurophysiology
Compound muscle action potential
Peripheral nerve stimulation
Motor unit number estimation
MUNE
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Thu, 27 Jun 2013, 18:25:39 EST by Dr Mark Bellingham on behalf of School of Biomedical Sciences