Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

West, Nicholas P., Cergol, Katie M., Xue, Millie, Randall, Elizabeth J., Britton, Warwick J. and Payne, Richard J. (2011) Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chemical Communications, 47 18: 5166-5168. doi:10.1039/c0cc05635a


Author West, Nicholas P.
Cergol, Katie M.
Xue, Millie
Randall, Elizabeth J.
Britton, Warwick J.
Payne, Richard J.
Title Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads
Journal name Chemical Communications   Check publisher's open access policy
ISSN 1359-7345
1364-548X
Publication date 2011-01
Year available 2011
Sub-type Article (original research)
DOI 10.1039/c0cc05635a
Open Access Status
Volume 47
Issue 18
Start page 5166
End page 5168
Total pages 3
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Collection year 2011
Language eng
Formatted abstract
The first targeted inhibitors of an essential M. tuberculosis cell wall lipase, Rv3802c, are described. Lead compounds exhibited nanomolar inhibition of the enzyme, and encouraging antibacterial activity against M. tuberculosis in vitro, supporting Rv3802c as a novel TB drug target. 
Keyword Alamar Blue Assay
Identification
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 22 times in Scopus Article | Citations
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