Modulation of Shigella virulence in response to available oxygen in vivo

Marteyn, Benoit, West, Nicholas P., Browning, Douglas F., Cole, Jeffery A., Shaw, Jonathan G., Palm, Fredrik, Mounier, Joelle, Prevost, Marie-Christine, Sansonetti, Philippe and Tang, Christoph M. (2010) Modulation of Shigella virulence in response to available oxygen in vivo. Nature, 465 7296: 355-358+2. doi:10.1038/nature08970

Author Marteyn, Benoit
West, Nicholas P.
Browning, Douglas F.
Cole, Jeffery A.
Shaw, Jonathan G.
Palm, Fredrik
Mounier, Joelle
Prevost, Marie-Christine
Sansonetti, Philippe
Tang, Christoph M.
Title Modulation of Shigella virulence in response to available oxygen in vivo
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2010-05
Year available 2010
Sub-type Article (original research)
DOI 10.1038/nature08970
Open Access Status
Volume 465
Issue 7296
Start page 355
End page 358+2
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2010
Language eng
Formatted abstract
 Bacteria coordinate expression of virulence determinants in response to localized microenvironments in their hosts. Here we show that Shigella flexneri, which causes dysentery, encounters varying oxygen concentrations in the gastrointestinal tract, which govern activity of its type three secretion system (T3SS). The T3SS is essential for cell invasion and virulence1. In anaerobic environments (for example, the gastrointestinal tract lumen), Shigella is primed for invasion and expresses extended T3SS needles while reducing Ipa (invasion plasmid antigen) effector secretion. This is mediated by FNR (fumarate and nitrate reduction), a regulator of anaerobic metabolism that represses transcription of spa32 and spa33, virulence genes that regulate secretion through the T3SS. We demonstrate there is a zone of relative oxygenation adjacent to the gastrointestinal tract mucosa, caused by diffusion from the capillary network at the tips of villi. This would reverse the anaerobic block of Ipa secretion, allowing T3SS activation at its precise site of action, enhancing invasion and virulence.
Keyword Hypoxia inducible factor
Chromosomal Genes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 117 times in Thomson Reuters Web of Science Article | Citations
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