Influence of particle size on the direct compression of ibuprofen and its binary mixtures

Liu, L. X., Marziano, I., Bentham, A. C., Litster, J. D., White, E. T. and Howes, T. (2013) Influence of particle size on the direct compression of ibuprofen and its binary mixtures. Powder Technology, 240 66-73. doi:10.1016/j.powtec.2012.07.006

Author Liu, L. X.
Marziano, I.
Bentham, A. C.
Litster, J. D.
White, E. T.
Howes, T.
Title Influence of particle size on the direct compression of ibuprofen and its binary mixtures
Journal name Powder Technology   Check publisher's open access policy
ISSN 0032-5910
Publication date 2013-05
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.powtec.2012.07.006
Volume 240
Start page 66
End page 73
Total pages 8
Place of publication Lausanne, Switzerland
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
In this paper, ibuprofen from a commercial source and its fractioned samples with narrower size distribution were characterized to assess the effect of particle properties on compaction characteristics. The compaction behavior of binary mixtures of ibuprofen with spray-dried lactose was also studied. The tablet in-die densification rate and tablet out-of-die porosity and tensile strength were measured for all samples. It was found that the particle size of ibuprofen does not affect the yield stress as derived from a Heckel plot, however the yield stress increases with the increase of ibuprofen particle size in the binary mixtures. Particle size also affects the tablet out-of-die properties, with tablet porosity and tensile strength increasing with the decrease in particle size. The effect of adding a weak compacting powder such as lactose on the tablet tensile strength is very much dependent on the ibuprofen particle size and mass ratio of the binary mixtures.  Mixing lactose with ibuprofen of similar size in equal mass has no effect on the tensile strength of the tablet whereas mixing it with ibuprofen of larger size reduces the strength compared to ibuprofen alone. Adding a smaller amount of lactose can lead to an increase in tablet strength, even though the particle size of ibuprofen and lactose is quite different. Theoretical analysis on the tablet strength based on particle–particle bond strength was also carried out to explain the experimental results.
Keyword Ibuprofen
Particle size
Binary mixtures
Powder Mixtures
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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