Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia

Schwab, Sibylle G., Kusumawardhani, Agung A. A. A., Dai, Nan, Qin, WenWen, Wildenauer, Mutiara D. B., Agiananda, Feranindhya, Amir, Nurmiati, Antoni, Ronald, Arsianti, Tiana, Asmarahadi, Asmarahadi, Diatri, Hervita, Djatmiko, Prianto, Irmansyah, Irmansyah, Khalimah, Siti, Kusumadewi, Irmia, Kusumaningrum, Profitasari, Lukman, Petrin R., Mustar, Lukman, Nasrun, Martina W., Naswati, Safyuni, Prasetiyawan, Prasetiyawan, Semen, Gerald M., Siste, Kristiana, Tobing, Heriani, Widiasih, Natalia, Wiguna, Tjhin, Wulandari, Widayanti Dewi, Benyamin, Beben and Wildenauer, Dieter B. (2013) Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia. Schizophrenia Research, 147 1: 46-52. doi:10.1016/j.schres.2013.03.022

Author Schwab, Sibylle G.
Kusumawardhani, Agung A. A. A.
Dai, Nan
Qin, WenWen
Wildenauer, Mutiara D. B.
Agiananda, Feranindhya
Amir, Nurmiati
Antoni, Ronald
Arsianti, Tiana
Asmarahadi, Asmarahadi
Diatri, Hervita
Djatmiko, Prianto
Irmansyah, Irmansyah
Khalimah, Siti
Kusumadewi, Irmia
Kusumaningrum, Profitasari
Lukman, Petrin R.
Mustar, Lukman
Nasrun, Martina W.
Naswati, Safyuni
Prasetiyawan, Prasetiyawan
Semen, Gerald M.
Siste, Kristiana
Tobing, Heriani
Widiasih, Natalia
Wiguna, Tjhin
Wulandari, Widayanti Dewi
Benyamin, Beben
Wildenauer, Dieter B.
Title Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
Publication date 2013-06
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.schres.2013.03.022
Open Access Status
Volume 147
Issue 1
Start page 46
End page 52
Total pages 7
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Background: Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background.

Methods: We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR-RFLP assay for confirmation of rs1344706 genotypes.

Results: We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P = 0.019, OR = 1.155, 95%, CI 1.025-1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706.

Conclusion: We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.
Keyword Zinc finger protein ZNF804A
Association study
Indonesian population
Asian ancestral background
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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