Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting

Zschau, Nora B., Andrews, Jane M., Holloway, Richard H., Schoeman, Mark N., Lange, Kylie, Tam, William C. E. and Holtmann, Gerald J. (2013) Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting. World Journal of Gastroenterology, 19 16: 2514-2520. doi:10.3748/wjg.v19.i16.2514

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Author Zschau, Nora B.
Andrews, Jane M.
Holloway, Richard H.
Schoeman, Mark N.
Lange, Kylie
Tam, William C. E.
Holtmann, Gerald J.
Title Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting
Journal name World Journal of Gastroenterology   Check publisher's open access policy
ISSN 1007-9327
Publication date 2013-04-28
Sub-type Article (original research)
DOI 10.3748/wjg.v19.i16.2514
Open Access Status DOI
Volume 19
Issue 16
Start page 2514
End page 2520
Total pages 7
Place of publication Beijing, China
Publisher Baishideng Publishing Group
Collection year 2014
Language eng
Formatted abstract
Aim: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy.

Methods: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study. The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed.

Results: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e., after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement.

Conclusion: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy.
Keyword Gastroesophageal reflux disease
Proton pump inhibitor
Acid suppressive therapy
Barrett's esophagus
Functional gastrointestinal disorders
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 16 Jun 2013, 00:16:12 EST by System User on behalf of School of Medicine