Nanodumbbells as multi-functional diagnosis probes

Wang, Hui, Rauf, Sakandar, Padmanabhan, Harish and Dimitrov, Krassen (2013) Nanodumbbells as multi-functional diagnosis probes. Journal of Nanoparticle Research, 15 5: 1633.1-1633.9. doi:10.1007/s11051-013-1633-2

Author Wang, Hui
Rauf, Sakandar
Padmanabhan, Harish
Dimitrov, Krassen
Title Nanodumbbells as multi-functional diagnosis probes
Journal name Journal of Nanoparticle Research   Check publisher's open access policy
ISSN 1388-0764
Publication date 2013-04
Sub-type Article (original research)
DOI 10.1007/s11051-013-1633-2
Volume 15
Issue 5
Start page 1633.1
End page 1633.9
Total pages 9
Place of publication Netherlands
Publisher Springer Netherlands
Collection year 2014
Language eng
Formatted abstract
In this study, we present a method to generate multi-functional nanometre dumbbell structure, which comprises a cobalt magnetic and a gold nanoparticle bridged by target biomarker. Both cobalt magnetic and gold nanoparticles were successfully modified with two different monoclonal antibodies, which will specifically bind to target antigen. ELISA results confirmed that the activities of those antibodies were not lost due to the conjugation to nanoparticles. The formation of dumbbell structure with the presence of target biomarker molecule was demonstrated via scanning electron microscope. The success of this study allows us to apply this featured dumbbell structure into a nanoelectrode device for digital detection of diagnostic biomarker in the next step.
Keyword Dumbbell structure
Gold nanoparticles
Cobalt magnetic nanoparticles
Diagnosis probes
Au-Fe3O4 nanoparticles
Colloidal gold
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Created: Sun, 16 Jun 2013, 00:11:52 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology