The olivo-cerebellar system and its relationship to survival circuits

Watson, Thomas C., Koutsikou, Stella, Cerminara, Nadia L., Flavell, Charlotte R., Crook, Jonathan J., Lumb, Bridget M. and Apps, Richard (2013) The olivo-cerebellar system and its relationship to survival circuits. Frontiers in Neural Circuits, 7 72: 1-7. doi:10.3389/fncir.2013.00072

Author Watson, Thomas C.
Koutsikou, Stella
Cerminara, Nadia L.
Flavell, Charlotte R.
Crook, Jonathan J.
Lumb, Bridget M.
Apps, Richard
Title The olivo-cerebellar system and its relationship to survival circuits
Journal name Frontiers in Neural Circuits   Check publisher's open access policy
ISSN 1662-5110
Publication date 2013-04-23
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fncir.2013.00072
Open Access Status DOI
Volume 7
Issue 72
Start page 1
End page 7
Total pages 7
Place of publication Switzerland
Publisher Frontiers Research Foundation
Collection year 2014
Language eng
Formatted abstract
How does the cerebellum, the brain’s largest sensorimotor structure, contribute to complex behaviors essential to survival? While we know much about the role of limbic and closely associated brainstem structures in relation to a variety of emotional, sensory, or motivational stimuli, we know very little about how these circuits interact with the cerebellum to generate appropriate patterns of behavioral response. Here we focus on evidence suggesting that the olivo-cerebellar system may link to survival networks via interactions with the midbrain periaqueductal gray, a structure with a well known role in expression of survival responses. As a result of this interaction we argue that, in addition to important roles in motor control, the inferior olive, and related olivo-cortico-nuclear circuits, should be considered part of a larger network of brain structures involved in coordinating survival behavior through the selective relaying of “teaching signals” arising from higher centers associated with emotional behaviors.
Keyword Cerebellum
Inferior olive
Periaqueductal gray
Midbrain periaqueductal gray
Transcranial magnetic stimulation
Unmyelinated heat nociceptors
Pontine reticular-hormation
Dorsal-horn neurons
Columnar organization
Conditioned fear
Emotional expression
Neurological disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2014 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 16 Jun 2013, 00:01:47 EST by System User on behalf of Queensland Brain Institute