Intrahost evolutionary dynamics of canine influenza virus in naïve and partially immune dogs

Hoelzer, Karin, Murcia, Pablo R., Baillie, Gregory J., Wood, James L. N., Metzger, Stephan M., Osterrieder, Nikolaus, Dubovi, Edward J., Holmes, Edward C. and Parrish, Colin R. (2010) Intrahost evolutionary dynamics of canine influenza virus in naïve and partially immune dogs. Journal of Virology, 84 10: 5329-5335. doi:10.1128/JVI.02469-09


Author Hoelzer, Karin
Murcia, Pablo R.
Baillie, Gregory J.
Wood, James L. N.
Metzger, Stephan M.
Osterrieder, Nikolaus
Dubovi, Edward J.
Holmes, Edward C.
Parrish, Colin R.
Title Intrahost evolutionary dynamics of canine influenza virus in naïve and partially immune dogs
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2010-05
Year available 2010
Sub-type Article (original research)
DOI 10.1128/JVI.02469-09
Open Access Status DOI
Volume 84
Issue 10
Start page 5329
End page 5335
Total pages 7
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract The patterns and dynamics of evolution in acutely infecting viruses within individual hosts are largely unknown. To this end, we investigated the intrahost variation of canine influenza virus (CIV) during the course of experimental infections in naïve and partially immune dogs and in naturally infected dogs. Tracing sequence diversity in the gene encoding domain 1 of the hemagglutinin (HA1) protein over the time course of infection provided information on the patterns and processes of intrahost viral evolution and revealed some of the effects of partial host immunity. Viral populations sampled on any given day were generally characterized by mean pairwise genetic diversities between 0.1 and 0.2% and by mutational spectra that changed considerably on different days. Some observed mutations may have affected antigenicity or host range, including reversions of CIV host-associated mutations. Patterns of sequence diversity differed between naïve and vaccinated dogs, with some presumably antigenic mutations transiently reaching high frequency in the latter. CIV populations are therefore characterized by the rapid generation and clearance of genetic diversity. Potentially advantageous mutations arise readily during the course of single infections and may give rise to antigenic escape or host range variants.
Keyword Host
Transmission
Infection
Diseases
Canine influenza virus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Fri, 14 Jun 2013, 11:20:23 EST by Gregory Baillie on behalf of Institute for Molecular Bioscience