Estimating reassortment rates in co-circulating Eurasian swine influenza viruses

Lycett, S. J., Baillie, G., Coulter, E., Bhatt, S., Kellam, P., McCauley, J. W., Wood, J. L. N., Brown, I. H., Pybus, O. G. and Brown, A. J. Leigh (2012) Estimating reassortment rates in co-circulating Eurasian swine influenza viruses. Journal of General Virology, 93 11: 2326-2336. doi:10.1099/vir.0.044503-0

Author Lycett, S. J.
Baillie, G.
Coulter, E.
Bhatt, S.
Kellam, P.
McCauley, J. W.
Wood, J. L. N.
Brown, I. H.
Pybus, O. G.
Brown, A. J. Leigh
Title Estimating reassortment rates in co-circulating Eurasian swine influenza viruses
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 0022-1317
Publication date 2012-11
Year available 2012
Sub-type Article (original research)
DOI 10.1099/vir.0.044503-0
Volume 93
Issue 11
Start page 2326
End page 2336
Total pages 11
Place of publication Reading, Berks, United Kingdom
Publisher Society for General Microbiology
Collection year 2013
Language eng
Formatted abstract
Swine have often been considered as a mixing vessel for different influenza strains. In order to assess their role in more detail, we undertook a retrospective sequencing study to detect and characterize the reassortants present in European swine and to estimate the rate of reassortment between H1N1, H1N2 and H3N2 subtypes with Eurasian (avian-like) internal protein-coding segments. We analysed 69 newly obtained whole genome sequences of subtypes H1N1-H3N2 from swine influenza viruses sampled between 1982 and 2008, using Illumina and 454 platforms. Analyses of these genomes, together with previously published genomes, revealed a large monophyletic clade of Eurasian swine-lineage polymerase segments containing H1N1, H1N2 and H3N2 subtypes. We subsequently examined reassortments between the haemagglutinin and neuraminidase segments and estimated the reassortment rates between lineages using a recently developed evolutionary analysis method. High rates of reassortment between H1N2 and H1N1 Eurasian swine lineages were detected in European strains, with an average of one reassortment every 2-3 years. This rapid reassortment results from co-circulating lineages in swine, and in consequence we should expect further reassortments between currently circulating swine strains and the recent swine-origin H1N1v pandemic strain.
Keyword Pandemic H1N1 2009
Receptor-Binding Properties
A H3N2 Viruses
Genetic Reassortment
United States
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 14 Jun 2013, 11:16:43 EST by Gregory Baillie on behalf of Institute for Molecular Bioscience