Association between obesity and atopic disorders in Chinese adults: an individually matched case-control study

Luo, Xiao, Xiang, Jing, Dong, Xiaohui, Cai, Fuwen, Suo, Jianing, Wang, Zhiqiang and Liu, Meina (2013) Association between obesity and atopic disorders in Chinese adults: an individually matched case-control study. BMC Public Health, 13 1: 12.1-12.5. doi:10.1186/1471-2458-13-12


Author Luo, Xiao
Xiang, Jing
Dong, Xiaohui
Cai, Fuwen
Suo, Jianing
Wang, Zhiqiang
Liu, Meina
Title Association between obesity and atopic disorders in Chinese adults: an individually matched case-control study
Journal name BMC Public Health   Check publisher's open access policy
ISSN 1471-2458
Publication date 2013-01
Sub-type Article (original research)
DOI 10.1186/1471-2458-13-12
Open Access Status DOI
Volume 13
Issue 1
Start page 12.1
End page 12.5
Total pages 5
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2014
Language eng
Formatted abstract
Background: Obesity is regarded as a potential risk factor for atopy. The aim of this study was to assess the associations of obesity with atopic dermatitis, rhinitis, asthma and food allergy in Chinese adults.

Methods: Two hundred and sixty six (266) atopic cases in Harbin, China, were identified according to the current Chinese guidelines for the diagnosis of atopic diseases. All cases had a previous diagnosis of atopic disorders (atopic dermatitis, rhinitis, asthma or food allergy) and were positive in one or more allergen specific IgE tests to 16 common allergens in the region. Each case was individually matched to two healthy controls based on their age, sex, and residential regions. All 532 healthy controls were negative in allergen specific IgE tests. The associations of obesity with four atopic disorders were assessed using a conditional logistic regression method.

Results: Obesity was significantly associated with the presence of atopic diseases (OR = 3.2, 95% CI: 1.8, 5.7). Males and females had a similar association (OR = 3.1 for males and 3.2 for females). The associations of obesity with atopic dermatitis (OR = 2.7, 95% CI: 1.2, 6.3) and atopic rhinitis (OR = 3.1, 95% CI: 1.1, 8.7) were statistically significant. Although obesity was positively associated with atopic asthma, this association was not statistically significant (OR = 3.4, 95% CI: 0.6, 19.9). The association between obesity and food allergy was weak and not significant (OR = 1.1, 95% CI: 0.4, 3.7).

Conclusions: Obesity is positively associated with the presence of atopic diseases in Chinese adults. Specifically, obesity is significantly associated with atopic dermatitis and rhinitis. Our findings warrant further investigation on the causal nature between obesity and atopic diseases and the effect of weight reduction on preventing atopic diseases.
Keyword Obesity
Atopy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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