Markers of disease severity are associated with malnutrition in Parkinson's disease

Sheard, Jamie M., Ash, Susan, Mellick, George D., Silburn, Peter A. and Kerr, Graham K. (2013) Markers of disease severity are associated with malnutrition in Parkinson's disease. PLoS One, 8 3: e57986.1-e57986.8. doi:10.1371/journal.pone.0057986


Author Sheard, Jamie M.
Ash, Susan
Mellick, George D.
Silburn, Peter A.
Kerr, Graham K.
Title Markers of disease severity are associated with malnutrition in Parkinson's disease
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-03
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0057986
Open Access Status DOI
Volume 8
Issue 3
Start page e57986.1
End page e57986.8
Total pages 8
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2014
Language eng
Formatted abstract
Objective: In Parkinson's disease (PD), commonly reported risk factors for malnutrition in other populations commonly occur. Few studies have explored which of these factors are of particular importance in malnutrition in PD. The aim was to identify the determinants of nutritional status in people with Parkinson's disease (PWP).

Methods:
Community-dwelling PWP (>18 years) were recruited (n = 125; 73M/52F; Mdn 70 years). Self-report assessments included Beck's Depression Inventory (BDI), Spielberger Trait Anxiety Inventory (STAI), Scales for Outcomes in Parkinson's disease - Autonomic (SCOPA-AUT), Modified Constipation Assessment Scale (MCAS) and Freezing of Gait Questionnaire (FOG-Q). Information about age, PD duration, medications, co-morbid conditions and living situation was obtained. Addenbrooke's Cognitive Examination (ACE-R), Unified Parkinson's Disease Rating Scale (UPDRS) II and UPDRS III were performed. Nutritional status was assessed using the Subjective Global Assessment (SGA) as part of the scored Patient-Generated Subjective Global Assessment (PG-SGA).

Results: Nineteen (15%) were malnourished (SGA-B). Median PG-SGA score was 3. More of the malnourished were elderly (84% vs. 71%) and had more severe disease (H&Y: 21% vs. 5%). UPDRS II and UPDRS III scores and levodopa equivalent daily dose (LEDD)/body weight(mg/kg) were significantly higher in the malnourished (Mdn 18 vs. 15; 20 vs. 15; 10.1 vs. 7.6 respectively). Regression analyses revealed older age at diagnosis, higher LEDD/body weight (mg/kg), greater UPDRS III score, lower STAI score and higher BDI score as significant predictors of malnutrition (SGA-B). Living alone and higher BDI and UPDRS III scores were significant predictors of a higher log-adjusted PG-SGA score.

Conclusions: In this sample of PWP, the rate of malnutrition was higher than that previously reported in the general community. Nutrition screening should occur regularly in those with more severe disease and depression. Community support should be provided to PWP living alone. Dopaminergic medication should be reviewed with body weight changes.
Keyword Body composition
Older Adults
Nutritional status
Weight loss
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Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 09 Jun 2013, 00:39:39 EST by System User on behalf of UQ Centre for Clinical Research