The distribution of Henipaviruses in Southeast Asia and Australasia: is Wallace's Line a Barrier to Nipah Virus?

Breed, Andrew C., Meers, Joanne, Sendow, Indrawati, Bossart, Katharine N., Barr, Jennifer A., Smith, Ina, Wacharapluesadee, Supaporn, Wang, Linfa and Field, Hume E. (2013) The distribution of Henipaviruses in Southeast Asia and Australasia: is Wallace's Line a Barrier to Nipah Virus?. PLoS One, 8 4: e61316.1-e61316.8. doi:10.1371/journal.pone.0061316

Author Breed, Andrew C.
Meers, Joanne
Sendow, Indrawati
Bossart, Katharine N.
Barr, Jennifer A.
Smith, Ina
Wacharapluesadee, Supaporn
Wang, Linfa
Field, Hume E.
Title The distribution of Henipaviruses in Southeast Asia and Australasia: is Wallace's Line a Barrier to Nipah Virus?
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-04
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0061316
Open Access Status DOI
Volume 8
Issue 4
Start page e61316.1
End page e61316.8
Total pages 8
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2014
Language eng
Formatted abstract
Nipah virus (NiV) (Genus Henipavirus) is a recently emerged zoonotic virus that causes severe disease in humans and has been found in bats of the genus Pteropus. Whilst NiV has not been detected in Australia, evidence for NiV-infection has been found in pteropid bats in some of Australia's closest neighbours. The aim of this study was to determine the occurrence of henipaviruses in fruit bat (Family Pteropodidae) populations to the north of Australia. In particular we tested the hypothesis that Nipah virus is restricted to west of Wallace's Line. Fruit bats from Australia, Papua New Guinea, East Timor and Indonesia were tested for the presence of antibodies to Hendra virus (HeV) and Nipah virus, and tested for the presence of HeV, NiV or henipavirus RNA by PCR. Evidence was found for the presence of Nipah virus in both Pteropus vampyrus and Rousettus amplexicaudatus populations from East Timor. Serology and PCR also suggested the presence of a henipavirus that was neither HeV nor NiV in Pteropus alecto and Acerodon celebensis. The results demonstrate the presence of NiV in the fruit bat populations on the eastern side of Wallace's Line and within 500 km of Australia. They indicate the presence of non-NiV, non-HeV henipaviruses in fruit bat populations of Sulawesi and Sumba and possibly in Papua New Guinea. It appears that NiV is present where P. vampyrus occurs, such as in the fruit bat populations of Timor, but where this bat species is absent other henipaviruses may be present, as on Sulawesi and Sumba. Evidence was obtained for the presence henipaviruses in the non-Pteropid species R. amplexicaudatus and in A. celebensis. The findings of this work fill some gaps in knowledge in geographical and species distribution of henipaviruses in Australasia which will contribute to planning of risk management and surveillance activities.
Keyword Pteropus Vampyrus Bats
Flying foxes
Hendra Virus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Veterinary Science Publications
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