Management of HIV-infected patients with MDR- and XDR-TB in resource-limited settings

Scano, F., Vitoria, M., Burman, W., Harries, A. D., Gilks, C. F. and Havlir, D. (2008) Management of HIV-infected patients with MDR- and XDR-TB in resource-limited settings. International Journal of Tuberculosis and Lung Disease, 12 12: 1370-1375.

Author Scano, F.
Vitoria, M.
Burman, W.
Harries, A. D.
Gilks, C. F.
Havlir, D.
Title Management of HIV-infected patients with MDR- and XDR-TB in resource-limited settings
Journal name International Journal of Tuberculosis and Lung Disease   Check publisher's open access policy
ISSN 1027-3719
1815-7920
Publication date 2008-12
Sub-type Critical review of research, literature review, critical commentary
Open Access Status
Volume 12
Issue 12
Start page 1370
End page 1375
Total pages 6
Place of publication Paris, France
Publisher International Union against Tuberculosis and Lung Disease
Language eng
Abstract The emergence of extensively drug-resistant tuberculosis (XDR-TB) poses a significant public health threat for human immunodeficiency virus (HIV) programmes and tuberculosis (TB) control efforts. Recent reports demonstrate high mortality rates among HIV-infected multidrug-resistant (MDR) and XDR-TB patients compared to those without HIV infection. Transmission of these highly resistant TB strains is occurring both within health facilities and in the community. We review the principles of a sound public health approach to this problem, including early diagnosis, treatment for suspected disease, patient support and adherence and sound infection control measures. In the context of drug-resistant TB, we elaborate on current World Health Organization antiretroviral guidelines addressing management issues related to timing of antiretroviral treatment (ART), drug interactions and drug toxicities among patients receiving both ART and second-line TB regimens. We highlight the important research agenda that exists at the intersection of MDR- and XDR-TB and HIV disease.
Keyword ART
MDR
XDR
Tuberculosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Public Health Publications
 
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