Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings

Meintjes, Graeme, Lawn, Stephen D., Scano, Fabio, Maartens, Gary, French, Martyn A., Worodria, William, Elliott, Julian H., Murdoch, David, Wilkinson, Robert J., Seyler, Catherine, John, Laurence, van der Loeff, Maarten Schim, Reiss, Peter, Lynen, Lut, Janoff, Edward N., Gilks, Charles and Colebunders, Robert (2008) Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infectious Diseases, 8 8: 516-523. doi:10.1016/S1473-3099(08)70184-1


Author Meintjes, Graeme
Lawn, Stephen D.
Scano, Fabio
Maartens, Gary
French, Martyn A.
Worodria, William
Elliott, Julian H.
Murdoch, David
Wilkinson, Robert J.
Seyler, Catherine
John, Laurence
van der Loeff, Maarten Schim
Reiss, Peter
Lynen, Lut
Janoff, Edward N.
Gilks, Charles
Colebunders, Robert
Title Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
Journal name Lancet Infectious Diseases   Check publisher's open access policy
ISSN 1473-3099
1474-4457
Publication date 2008-08
Year available 2008
Sub-type Article (original research)
DOI 10.1016/S1473-3099(08)70184-1
Open Access Status
Volume 8
Issue 8
Start page 516
End page 523
Total pages 8
Place of publication London, United Kingdom
Publisher The Lancet Publishing Group
Collection year 2008
Language eng
Formatted abstract
The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed case definitions are not readily applicable in settings where laboratory resources are limited. As a result, existing studies on tuberculosis-associated IRIS have used a variety of non-standardised general case definitions. To rectify this problem, around 100 researchers, including microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, and public-health specialists from 16 countries met in Kampala, Uganda, in November, 2006. At this meeting, consensus case definitions for paradoxical tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking tuberculosis-associated IRIS were derived, which can be used in high-income and resource-limited settings. It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data.
Keyword Active Antiretroviral Therapy
Hiv Infected Patients
Risk Factors
Virological Responses
South Africa
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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