Slaving and release in co-infection control

Yakob, Laith, Williams, Gail M., Gray, Darren J., Halton, Kate, Solon, Juan Antonio and Clements, Archie C. A. (2013) Slaving and release in co-infection control. Parasites & Vectors, 6 157.1-157.9. doi:10.1186/1756-3305-6-157

Author Yakob, Laith
Williams, Gail M.
Gray, Darren J.
Halton, Kate
Solon, Juan Antonio
Clements, Archie C. A.
Title Slaving and release in co-infection control
Journal name Parasites & Vectors   Check publisher's open access policy
ISSN 1756-3305
Publication date 2013-05-31
Sub-type Article (original research)
DOI 10.1186/1756-3305-6-157
Open Access Status DOI
Volume 6
Start page 157.1
End page 157.9
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2014
Language eng
Formatted abstract
Background: Animal and human infection with multiple parasite species is the norm rather than the exception,
and empirical studies and animal models have provided evidence for a diverse range of interactions among
parasites. We demonstrate how an optimal control strategy should be tailored to the pathogen community and
tempered by species-level knowledge of drug sensitivity with use of a simple epidemiological model of gastrointestinal
Methods: We construct a fully mechanistic model of macroparasite co-infection and use it to explore a range of
control scenarios involving chemotherapy as well as improvements to sanitation.
Results: Scenarios are presented whereby control not only releases a more resistant parasite from antagonistic
interactions, but risks increasing co-infection rates, exacerbating the burden of disease. In contrast, synergisms
between species result in their becoming epidemiologically slaved within hosts, presenting a novel opportunity for
controlling drug resistant parasites by targeting co-circulating species.
Conclusions: Understanding the effects on control of multi-parasite species interactions, and vice versa, is of
increasing urgency in the advent of integrated mass intervention programmes.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 157

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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Created: Wed, 05 Jun 2013, 14:18:26 EST by Dr Laith Yakob on behalf of School of Public Health