Ciguatera and mannitol: Experience with a new treatment regimen

Pearn, JH, Lewis, RJ, Ruff, T, Tait, M, Quinn, J, Murtha, W, King, G, Mallett, A and Gillespie, NC (1989) Ciguatera and mannitol: Experience with a new treatment regimen. Medical Journal of Australia, 151 2: 77-80.

Author Pearn, JH
Lewis, RJ
Ruff, T
Tait, M
Quinn, J
Murtha, W
King, G
Mallett, A
Gillespie, NC
Title Ciguatera and mannitol: Experience with a new treatment regimen
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
Publication date 1989-07
Year available 1989
Sub-type Article (original research)
Open Access Status
Volume 151
Issue 2
Start page 77
End page 80
Total pages 4
Place of publication Strawberry Hills, Australia
Publisher Australasian Medical Publishing Company
Language eng
Formatted abstract
Ciguatera is a distressing, hitherto-untreatable and not rare disease which results from the eating of ciguatoxin-contaminated fish from tropical and subtropical waters. We report here the results of a pilot study to assess the efficacy of mannitol therapy in ciguatera poisoning. Twelve adult patients (six men) have been treated, five of whom - who were ill acutely - experienced a significant benefit from this therapy, in three cases, with a hitherto-unexperienced dramatic reversal of symptons. We conclude that an intravenous infusion of 1.0 g/kg of mannitol which is given over 45 minutes, after rehydration if required, can be of significant benefit to at least some acutely intoxicated victims. We postulate either a reduction of axonal oedema, or a scavenger effect, or both, as the mechanism of the beneficial effects of mannitol. Ciguatoxin is rich in hydroxyl groups, and causes microscopic oedema of neural tissue. If our conclusion of the benefical effects of mannitol therapy is confirmed, this will offer the first effective therapy for acute phases of this disease, and has promise of preventing much long-term morbidity.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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