Mosaicism of solid gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype

Smit, Maria, Segers, Karin, Carrascosa, Laura Garcia, Shay, Tracy, Baraldi, Francesca, Gyapay, Gabor, Snowder, Gary, Georges, Gary, Cockett, Noelle and Charlier, Carole (2003) Mosaicism of solid gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype. Genetics, 163 1: 453-456.

Author Smit, Maria
Segers, Karin
Carrascosa, Laura Garcia
Shay, Tracy
Baraldi, Francesca
Gyapay, Gabor
Snowder, Gary
Georges, Gary
Cockett, Noelle
Charlier, Carole
Title Mosaicism of solid gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype
Journal name Genetics   Check publisher's open access policy
ISSN 0016-6731
Publication date 2003
Sub-type Article (original research)
Volume 163
Issue 1
Start page 453
End page 456
Total pages 4
Place of publication Bethesda, MD, United States
Publisher Genetics Society of America
Language eng
Abstract To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif between DLK1 and GTL2. This was the only difference found between the callipyge (CLPG) allele and a phylogenetically closely related wild-type allele. We report that this SNP is in perfect association with the callipyge genotype. The demonstration that Solid Gold - the alleged founder ram of the callipyge flock - is mosaic for this SNP virtually proves the causality of this SNPin the determinism of the callipyge phenotype.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Mon, 03 Jun 2013, 13:44:26 EST by Laura Garcia Carrascosa on behalf of Aust Institute for Bioengineering & Nanotechnology