Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy

Pizzichetta, Maria A., Massone, Cesare, Grandi, Giorgio, Pelizzo, Gloria and Soyer, H. Peter (2006) Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy. Archives of Dermatology, 142 4: 479-483. doi:10.1001/archderm.142.4.479


Author Pizzichetta, Maria A.
Massone, Cesare
Grandi, Giorgio
Pelizzo, Gloria
Soyer, H. Peter
Title Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy
Journal name Archives of Dermatology   Check publisher's open access policy
ISSN 0003-987X
2168-6084
Publication date 2006-04-01
Sub-type Article (original research)
DOI 10.1001/archderm.142.4.479
Open Access Status DOI
Volume 142
Issue 4
Start page 479
End page 483
Total pages 5
Place of publication Chicago, IL, United States
Publisher American Medical Association
Language eng
Formatted abstract
Background:  Melanocytic nevi with eccentric foci of hyperpigmentation (“Bolognia sign”) can be considered as a melanoma-simulating type of acquired melanocytic nevus. We report on the morphologic changes of this type of melanocytic nevus over a 39-month period of dermoscopic follow-up.

Observations:  A 5-year-old girl had a 4-mm brown papule with a peripheral blue-black area on her right upper arm. The eccentric focus of the hyperpigmentation corresponded dermoscopically to a blue-gray area of pigmentation associated with irregular brown-black globules or dots and partially with a superficial black network. After 39 months, a globular type of acquired melanocytic nevus was detectable, which clinically and dermoscopically appeared to be completely benign. A nearly identical situation was observed in 5 other melanocytic nevi, underlining the involution of the pigmented foci in these nevi. The histopathologic diagnoses of 2 lesions were consistent with a compound type of acquired melanocytic nevus with eccentric foci of hyperpigmentation.

Conclusions:  Dermoscopy allows identification of a morphologic pathway of modifications, probably typical for this type of melanocytic nevus in children, and therefore enables avoidance of surgical excision with attendant hypertrophic scarring in children. Conversely, in adults, when dermoscopic follow-up of melanocytic nevi reveals eccentric foci of hyperpigmentation, surgical excision of the lesion is indicated.
Keyword Clark Nevi
Melanoma
Lesions
Classification
Diagnosis
Benign
Risk
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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