Distinct expression patterns of syndecans in the embryonic zebrafish brain

Hofmeister, Wolfgang, Devine, Christine A. and Key, Brian (2013) Distinct expression patterns of syndecans in the embryonic zebrafish brain. Gene Expression Patterns, 13 3-4: 126-132. doi:10.1016/j.gep.2013.02.002


Author Hofmeister, Wolfgang
Devine, Christine A.
Key, Brian
Title Distinct expression patterns of syndecans in the embryonic zebrafish brain
Formatted title
Distinct expression patterns of syndecans in the embryonic zebrafish brain
Journal name Gene Expression Patterns   Check publisher's open access policy
ISSN 1567-133X
1872-7298
Publication date 2013-03-01
Sub-type Article (original research)
DOI 10.1016/j.gep.2013.02.002
Volume 13
Issue 3-4
Start page 126
End page 132
Total pages 7
Place of publication Netherlands
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Axon pathfinding in the neuroepithelium of embryonic brain is dependent on a variety of short and long range guidance cues. Heparan sulfate proteoglycans such as syndecans act as modulators of these cues and their importance in neural development is highlighted by their phylogenetic conservation. In Drosophilia, a single syndecan is present on the surface of axon growth cones and is required for chemorepulsive signalling during midline crossing. Understanding the role of syndecans in the vertebrate nervous system is challenging given that there are four homologous genes, syndecans 1–4. We show here that syndecans 2–4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.

Highlights sdc2, sdc3 and sdc4 are differentially expressed with minimal overlap. ► sdc3 associates with primary axon scaffold. ► sdc4 surrounds the post-optic commissure. ► sdc2, sdc3, sdc4 are expressed at the isthmus.
Keyword Heparan sulfate proteoglycans
Syndecans
Axon guidance
Axon pathway formation
In-situ hybridization
Heparan-sulfate
Gene-expression
Slit
Forebrain
Guidance
Wnt
Migration
Protein
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
 
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