Human papillomavirus, smoking status and outcomes in tonsillar squamous cell carcinoma

Hong, Angela M., Martin, Andrew, Chatfield, Mark, Jones, Deanna, Zhang, Mei, Armstrong, Bruce, Lee, C. Soon, Harnett, Gerald, Milross, Christopher, Clark, Jonathan, Elliott, Michael, Smee, Robert, Corry, June, Liu, Chen, Porceddu, Sandro, Rees, Guy and Rose, Barbara (2013) Human papillomavirus, smoking status and outcomes in tonsillar squamous cell carcinoma. International Journal of Cancer, 132 12: 2748-2754. doi:10.1002/ijc.27956

Author Hong, Angela M.
Martin, Andrew
Chatfield, Mark
Jones, Deanna
Zhang, Mei
Armstrong, Bruce
Lee, C. Soon
Harnett, Gerald
Milross, Christopher
Clark, Jonathan
Elliott, Michael
Smee, Robert
Corry, June
Liu, Chen
Porceddu, Sandro
Rees, Guy
Rose, Barbara
Title Human papillomavirus, smoking status and outcomes in tonsillar squamous cell carcinoma
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 2013-06-15
Year available 2012
Sub-type Article (original research)
DOI 10.1002/ijc.27956
Volume 132
Issue 12
Start page 2748
End page 2754
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2014
Language eng
Abstract It is now clear that the two separate entitles of tonsillar cancer, HPV induced and non-HPV induced (smoking induced), have significantly different presenting stage and outcomes. A significant proportion of patients with human papillomavirus positive tonsillar cancer have had exposure to smoking. We examined the combined effect of human papillomavirus and smoking on the outcomes and determined whether smoking can modify the beneficial effect of human papillomavirus. A total of 403 patients from nine centers were followed up for recurrence or death for a median of 38 months. Determinants of the rate of loco-regional recurrence, death from tonsillar cancer and overall survival were modeled using Cox regression. Smoking status was a significant predictor of overall survival (p = 0.04). There were nonstatistically significant trends favoring never smokers for loco-regional recurrence and disease specific survival. In addition, there was no statistically significant interactions between smoking and human papillomavirus (p-values for the interaction were 0.26 for loco-regional recurrence, 0.97 for disease specific survival and 0.73 for overall survival). The effect of smoking on loco-regional recurrence and disease specific survival outcomes was not statistically significant, nor was there significant evidence that the effect of smoking status on these outcomes was modified by HPV status. Irrespective of HPV status, however, smokers did have poorer overall survival than never-smokers, presumably due to effects of smoking that are unrelated to the primary cancer.
Keyword Oropharyngeal cancer
Human papillomavirus
Tonsillar cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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