Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period

Mackay, Ian M., Lambert, Stephen B., Faux, Cassandra E., Arden, Katherine E., Nissen, Michael D., Sloots, Theo P. and Nolan, Terence M. (2013) Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period. Journal of Infectious Diseases, 207 9: 1433-1441. doi:10.1093/infdis/jis476


Author Mackay, Ian M.
Lambert, Stephen B.
Faux, Cassandra E.
Arden, Katherine E.
Nissen, Michael D.
Sloots, Theo P.
Nolan, Terence M.
Title Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
1537-6613
Publication date 2013-05
Sub-type Article (original research)
DOI 10.1093/infdis/jis476
Open Access Status DOI
Volume 207
Issue 9
Start page 1433
End page 1441
Total pages 9
Place of publication Cary, NC, United States
Publisher Oxford University Press
Collection year 2014
Language eng
Abstract Human rhinovirus (HRV) replication triggers exacerbation of asthma and causes most acute respiratory illnesses (ARIs), which may manifest as influenza-like illness. The recent assignment of 60 previously unknown HRV types to a third HRV species, Human rhinovirus C, raised questions about the prevalence of these picornavirus types in the community, the extent of HRV diversity at a single site, and whether the HRVs have an equally diverse clinical impact on their hosts. We quantified HRV diversity, and there was no clinical impact attributable to HRV species and genotypes among a community population of preschool-aged children with ARI who provided respiratory samples during 2003. All HRV species were represented among 138 children with ARI, and 74 distinct HRV types were cocirculating. Fever accompanied 32.8% of HRV-positive ARI cases. HRVs were less likely than DNA viruses to be codetected with another virus, suggesting virus interference at the community level, demonstrated by the inverse correlation between influenza virus detection and HRV detection.
Keyword Human rhinovirus
Viral epidemiology
Virus:virus interactions
Co-detections
Influenza virus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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