Activation of BDNF signaling prevents the return of fear in female mice

Baker-Andresen, Danay, Flavell, Charlotte R., Li, Xiang and Bredy, Timothy W. (2013) Activation of BDNF signaling prevents the return of fear in female mice. Learning & Memory, 20 5: 237-240. doi:10.1101/lm.029520.112

Author Baker-Andresen, Danay
Flavell, Charlotte R.
Li, Xiang
Bredy, Timothy W.
Title Activation of BDNF signaling prevents the return of fear in female mice
Journal name Learning & Memory   Check publisher's open access policy
ISSN 1072-0502
Publication date 2013-05
Sub-type Article (original research)
DOI 10.1101/lm.029520.112
Open Access Status DOI
Volume 20
Issue 5
Start page 237
End page 240
Total pages 4
Place of publication Woodbury, NY, United States
Publisher Cold Spring Harbor Laboratory Press
Collection year 2014
Language eng
Abstract There are significant sex differences in vulnerability to develop fear-related anxiety disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males and sex differences have been observed in fear extinction learning in both humans and rodents, with a failure to inhibit fear emerging as a precipitating factor in the development of PTSD. Here we report that female mice are resistant to fear extinction, and exhibit increased DNA methylation of Bdnf exon IV and a concomitant decrease in mRNA expression within the medial prefrontal cortex. Activation of BDNF signaling by the trkB agonist 7,8-dihydroxyflavone blocks the return of fear in female mice after extinction training, and thus represents a novel approach to treating fear-related anxiety disorders that are characterized by a resistance to extinction and increased propensity for renewal.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 30 times in Scopus Article | Citations
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