Safety evaluation of leflunomide in rheumatoid arthritis

Keen, Helen I., Conaghan, Philip G. and Tett, Susan E. (2013) Safety evaluation of leflunomide in rheumatoid arthritis. Expert Opinion Drug Safety Evaluation, 12 4: 581-588. doi:10.1517/14740338.2013.798299


Author Keen, Helen I.
Conaghan, Philip G.
Tett, Susan E.
Title Safety evaluation of leflunomide in rheumatoid arthritis
Journal name Expert Opinion Drug Safety Evaluation   Check publisher's open access policy
ISSN 1474-0338
1744-764X
Publication date 2013-04-05
Sub-type Article (original research)
DOI 10.1517/14740338.2013.798299
Volume 12
Issue 4
Start page 581
End page 588
Total pages 8
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2014
Language eng
Formatted abstract
Introduction: Leflunomide is a prodrug which is rapidly converted following oral administration and absorption to an active metabolite with anti-proliferative effects (A77 1726/teriflunomide). Leflunomide was developed as an immunomodulatory agent and subsequently developed as a disease-modifying anti-rheumatic drug (DMARD) for the management of rheumatoid arthritis (RA).

Areas covered: This review article covers the mechanism of action of the drug, clinical indications, including efficacy data from clinical trials, safety data from clinical trials, post marketing studies and surveillance databases and safety in special populations. Additionally, the review discusses the current place of leflunomide in the management of RA, and its likely future as an anti-rheumatic drug.

Expert opinion: Leflunomide is a relatively safe drug, with proven efficacy in RA management. Its clinical use is limited by the historic parallel development of other agents, including methotrexate, which has become the synthetic DMARD of choice and biological DMARDs that have superior efficacy.
Keyword Leflunomide
Rheumatoid arthritis
Toxicity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Pharmacy Publications
 
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Created: Thu, 23 May 2013, 15:53:34 EST by Myrtle Sahabandu on behalf of School of Pharmacy