Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years

Calogero, Claudia, Simpson, Shannon J., Lombardi, Enrico, Parri, Niccolo, Cuomo, Barbara, Palumbo, Massimo, de Martino, Maurizio, Shackleton, Claire, Verheggen, Maureen, Gavidia, Tania, Franklin, Peter J, Kusel, Merci M. M., Park, Judy, Sly, Peter D. and Hall, Graham L. (2013) Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years. Pediatric Pulmonology, 48 7: 707-715. doi:10.1002/ppul.22699


Author Calogero, Claudia
Simpson, Shannon J.
Lombardi, Enrico
Parri, Niccolo
Cuomo, Barbara
Palumbo, Massimo
de Martino, Maurizio
Shackleton, Claire
Verheggen, Maureen
Gavidia, Tania
Franklin, Peter J
Kusel, Merci M. M.
Park, Judy
Sly, Peter D.
Hall, Graham L.
Title Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years
Journal name Pediatric Pulmonology   Check publisher's open access policy
ISSN 8755-6863
1099-0496
Publication date 2013-07
Sub-type Article (original research)
DOI 10.1002/ppul.22699
Open Access Status
Volume 48
Issue 7
Start page 707
End page 715
Total pages 9
Place of publication Hoboken, NJ, U.S.A.
Publisher John Wiley & Sons
Collection year 2013
Language eng
Formatted abstract
Background
The forced oscillation technique (FOT) can be used in children as young as 2 years of age and in those unable to perform routine spirometry. There is limited information on changes in FOT outcomes in healthy children beyond the preschool years and the level of bronchodilator responsiveness (BDR) in healthy children. We aimed to create reference ranges for respiratory impedance outcomes collated from multiple centers. Outcomes included respiratory system resistance (Rrs) and reactance (Xrs), resonant frequency (Fres), frequency dependence of Rrs (Fdep), and the area under the reactance curve (AX). We also aimed to define the physiological effects of bronchodilators in a large population of healthy children using the FOT.

Methods
Respiratory impedance was measured in 760 healthy children, aged 2-13 years, from Australia and Italy. Stepwise linear regression identified anthropometric predictors of transformed Rrs and Xrs at 6, 8, and 10 Hz, Fres, Fdep, and AX. Bronchodilator response (BDR) was assessed in 508 children after 200 μg of inhaled salbutamol. Results Regression analysis showed that Rrs, Xrs, and AX outcomes were dependent on height and sex. The BDR cut-offs by absolute change in Rrs8, X rs8, and AX were -2.74 hPa s L-1, 1.93 hPa s L -1, and -33 hPa s L-1, respectively. These corresponded to relative and Z-score changes of -32%; -1.85 for Rrs8, 65%; 1.95 for Xrs8, and -82%; -2.04 for AX.

Conclusions
We have established generalizable reference ranges for respiratory impedance and defined cut-offs for a positive bronchodilator response using the FOT in healthy children.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 20 NOV 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2013 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 14 May 2013, 12:46:13 EST by Matthew Lamb on behalf of School of Medicine