Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo

Coles, Daniel J., Rolfe, Barbara E., Boase, Nathan R. B., Veedu, Rakesh N. and Thurecht, Kristofer J. (2013) Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo. Chemical Communications, 49 37: 3836-3838. doi:10.1039/c3cc00127j


Author Coles, Daniel J.
Rolfe, Barbara E.
Boase, Nathan R. B.
Veedu, Rakesh N.
Thurecht, Kristofer J.
Title Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo
Formatted title
Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo
Journal name Chemical Communications   Check publisher's open access policy
ISSN 1359-7345
1364-548X
Publication date 2013-01-01
Sub-type Article (original research)
DOI 10.1039/c3cc00127j
Volume 49
Issue 37
Start page 3836
End page 3838
Total pages 3
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Collection year 2014
Language eng
Formatted abstract
Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer)
while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.
Keyword Drug-delivery
Therapy
Therapeutics
Perspectives
Nanomedicine
RAFT
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 12 May 2013, 11:20:52 EST by System User on behalf of Centre for Advanced Imaging