Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia

Denny, Kerina J., Coulthard, Liam G., Finnell, Richard H., Callaway, Leonie K., Taylor, Stephen M. and Woodruff, Trent M. (2013) Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia. Journal of Reproductive Immunology, 97 2: 211-216. doi:10.1016/j.jri.2012.11.006


Author Denny, Kerina J.
Coulthard, Liam G.
Finnell, Richard H.
Callaway, Leonie K.
Taylor, Stephen M.
Woodruff, Trent M.
Title Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia
Journal name Journal of Reproductive Immunology   Check publisher's open access policy
ISSN 0165-0378
1872-7603
Publication date 2013-04
Sub-type Article (original research)
DOI 10.1016/j.jri.2012.11.006
Volume 97
Issue 2
Start page 211
End page 216
Total pages 6
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Collection year 2014
Language eng
Abstract Preeclampsia is a leading cause of morbidity and mortality worldwide, encompassing significant short- and long-term health sequelae. Recently, there has been accumulating evidence for a role of the complement system in the pathogenesis of numerous complications of pregnancy, including preeclampsia. The present cross-sectional study compared the plasma concentrations of complement factors C3a and C5a between normotensive pregnancies and pregnancies complicated with either preeclampsia or gestational hypertension alone. We found that maternal plasma C5a concentration was significantly higher in preeclamptic pregnancy than in pregnancy affected by gestational hypertension alone or normotensive pregnancy. Umbilical cord plasma C5a concentrations were also higher in pregnancies complicated by preeclampsia compared to gestational hypertension or normotensive pregnancy. Maternal and cord plasma C5a concentrations were significantly correlated, suggesting that C5a can freely diffuse between maternal and fetal circulation. There were no significant differences in C3a concentrations in maternal or cord plasma between any groups. These results support the hypothesis that C5a may play a role in preeclampsia, but not in gestational hypertension.
Keyword Preeclampsia
Complement
Gestational hypertension
Pregnancy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
School of Medicine Publications
 
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