Extended spectrum beta-lactamases, carbapenemases and mobile genetic elements responsible for antibiotics resistance in Gram-negative bacteria

El Salabi, Allaaeddin, Walsh, Timothey R. and Chouchani, Chedly (2013) Extended spectrum beta-lactamases, carbapenemases and mobile genetic elements responsible for antibiotics resistance in Gram-negative bacteria. Critical Reviews in Microbiology, 39 2: 113-122. doi:10.3109/1040841X.2012.691870


Author El Salabi, Allaaeddin
Walsh, Timothey R.
Chouchani, Chedly
Title Extended spectrum beta-lactamases, carbapenemases and mobile genetic elements responsible for antibiotics resistance in Gram-negative bacteria
Formatted title
Extended spectrum β-lactamases, carbapenemases and mobile genetic elements responsible for antibiotics resistance in Gram-negative bacteria
Journal name Critical Reviews in Microbiology   Check publisher's open access policy
ISSN 1040-841X
1549-7828
Publication date 2013-05
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3109/1040841X.2012.691870
Volume 39
Issue 2
Start page 113
End page 122
Total pages 10
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2014
Language eng
Abstract Infectious diseases due to Gram-negative bacteria are a leading cause of morbidity and mortality worldwide. Antimicrobial agents represent one major therapeutic tools implicated to treat these infections. The misuse of antimicrobial agents has resulted in the emergence of resistant strains of Gram-negatives in particular Enterobacteriaceae and non-fermenters; they have an effect not only on a human but on the public health when bacteria use the resistance mechanisms to spread in the hospital environment and to the community outside the hospitals by means of mobile genetic elements. Gram-negative bacteria have become increasingly resistant to antimicrobial agents. They have developed several mechanisms by which they can withstand to antimicrobials, these mechanisms include the production of Extended-spectrum β-lactamases (ESBLs) and carbapenemases, furthermore, Gram-negative bacteria are now capable of spreading such resistance between members of the family Enterobacteriaceae and non-fermenters using mobile genetic elements as vehicles for such resistance mechanisms rendering antibiotics useless. Therefore, addressing the issue of mechanisms of antimicrobial resistance is considered one of most urgent priorities. This review will help to illustrate different resistance mechanisms; ESBLs, carbapenemases encoded by genes carried by mobile genetic elements, which are used by Gram-negative bacteria to escape antimicrobial effect.
Keyword Antibiotic resistance
ESBLs
MBLs
Carbapenemases
Gram-negative bacteria
Review
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
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