The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression

Ye, Ping, Zhao, Liang and Gonda, Thomas J. (2013) The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression. Leukemia Research, 37 5: 595-601. doi:10.1016/j.leukres.2013.01.012


Author Ye, Ping
Zhao, Liang
Gonda, Thomas J.
Title The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression
Formatted title
The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression
Journal name Leukemia Research   Check publisher's open access policy
ISSN 0145-2126
1873-5835
Publication date 2013-05
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.leukres.2013.01.012
Volume 37
Issue 5
Start page 595
End page 601
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2014
Language eng
Formatted abstract
RNA interference-mediated suppression of MYB expression promoted apoptosis in the AML cell line U937, without affecting expression of the anti-apoptotic MYB target BCL2. This was accompanied by up-regulation of the pro-apoptotic gene DRAK2 and stimulation of caspase-9 activity. Moreover, RNA interference-mediated suppression of DRAK2 in U937 cells alleviated apoptosis induced by MYB down-regulation. Finally ChIP assays showed that in U937 cells MYB binds to a conserved element upstream of the DRAK2 transcription start site. Together, these findings identify a novel mechanism by which MYB suppresses apoptosis in an AML model cell line.
Keyword Myb
Leukemia
Apoptosis
shRNA
Drak2/stk17B
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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