The enigma of IgE(+) B-cell memory in human subjects

Davies, Janet M., Platts-Mills, Thomas A. and Aalberse, Rob C. (2013) The enigma of IgE(+) B-cell memory in human subjects. Journal of Allergy and Clinical Immunology, 131 4: 972-976. doi:10.1016/j.jaci.2012.12.1569


Author Davies, Janet M.
Platts-Mills, Thomas A.
Aalberse, Rob C.
Title The enigma of IgE(+) B-cell memory in human subjects
Formatted title
The enigma of IgE+ B-cell memory in human subjects
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
1097-6825
1085-8725
Publication date 2013-04
Sub-type Article (original research)
DOI 10.1016/j.jaci.2012.12.1569
Volume 131
Issue 4
Start page 972
End page 976
Total pages 5
Place of publication United States
Publisher Mosby
Collection year 2014
Language eng
Formatted abstract
Our understanding of the origin and fate of the IgE-switched B cell has been markedly improved by studies in mouse models. The immediate precursor of the IgE-switched B cell is either a relatively naive nonswitched B cell or a mature IgG-switched B cell. These 2 routes are referred to as the direct and indirect pathways, respectively. IgE responses derived from each pathway differ significantly, largely reflecting the difference in time spent in a germinal center and thus time for clonal expansion, somatic hypermutation, affinity maturation, and acquisition of a memory phenotype. The clinical and therapeutic implications for IgE responses in human subjects are still a matter of debate, largely because the immunization procedures used in the animal models are significantly different from classical atopic sensitization to allergens from pollen and mites. On the basis of the limited information available, it seems likely that these atopic IgE responses are characterized by a relatively low IgG/IgE ratio, low B-cell memory, and modest affinity maturation, which fits well with the direct switching pathway. It is still unresolved how the IgE response evolves to cover a wide epitope repertoire involving many epitopes per allergen, as well as many different allergens from a single allergen source.
Keyword IgE
B cells
IgE(+) B cells
Memory B cells
Plasma cells
Allergy
Germinal center
Grass-pollen immunotherapy
Class switch recombination
Fc-epsilon-RI
Immunoglobulin-E
Nasal-mucosa
In-vivo
Allergen challenge
Rhinitis patients
Dendritic cells
Antigen-driven
FcεRI
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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