Parent cough-specific quality of life: development and validation of a short form

Newcombe, Peter A., Sheffield, Jeanie K. and Chang, Anne B. (2013) Parent cough-specific quality of life: development and validation of a short form. Journal of Allergy and Clinical Immunology, 131 4: 1069-1074. doi:10.1016/j.jaci.2012.10.004

Author Newcombe, Peter A.
Sheffield, Jeanie K.
Chang, Anne B.
Title Parent cough-specific quality of life: development and validation of a short form
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
Publication date 2013-04
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.jaci.2012.10.004
Open Access Status
Volume 131
Issue 4
Start page 1069
End page 1074
Total pages 6
Place of publication Mosby, Inc.
Publisher Philadelphia, PA, U.S.A.
Collection year 2014
Language eng
Abstract Background: Cough is a distressing symptom and has a significant effect on many children and their families. Quality-of-life (QOL) measures provide important outcome indicators for clinicians and aid in evaluating the efficacy of interventions. Objective: The aim of this study was to develop and validate a short cough-specific QOL questionnaire for pediatric use. Method: Two sources provided data to establish a shortened version of the Parent Cough-specific Quality of Life (PC-QOL)questionnaire. The first (n 5 240, 137 boys; median age, 29 months [interquartile range, 14-64 months]) was used for development and cross-validation. Stepwise regression was used to select the reduced set of items, and analyses of reliability,validity, and minimally important differences determined psychometric strength and sensitivity to change. The second independent dataset (n 5 320, 190 boys; median age, 39.5 months [interquartile range, 16-77 months]) was used as a confirmatory sample. Results: Forward-step regression identified 8 items that accounted for 95% of the variance in the full-scale PC-QOL questionnaire. This shortened version (PC-QOL-8) was internally consistent (Cronbach a 5 0.84), had good test-retest reliability (intraclass correlation coefficient 5 0.66), and demonstrated strong validity (significant correlations with a cough verbal category descriptor score, cough visual analog scale, and subscales of the Short Form-12 General Health scale, the Pediatric Quality of Life Inventory, and the Depression,Anxiety, and Stress Scale). The reduced scale was responsive to change, and a minimally important difference of 0.9 was suggested. These findings were confirmed with the second dataset. Conclusion: The PC-QOL-8 questionnaire is a short, reliable, and valid instrument for assessing the effect of a child’s chronic cough. It demonstrated sensitivity to change, and its length and psychometric properties should enhance its potential uptake and routine use in clinical practice and research.
Keyword Quality of life
pediatric cough
minimally important difference
Minimally Important Differences
Cystic Fibrosis Bronchiectasis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online November 10, 2012

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