Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

Dantas De Araujo, Aline, Herzig, Volker, Windley, Monique J., Dziemborowicz, Slawomir, Mobli, Mehdi, Nicholson, Graham M., Alewood, Paul F. and King, Glenn F. (2013) Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?. Antioxidants and Redox Signaling, 19 16: 1976-1980. doi:10.1089/ars.2013.5365


Author Dantas De Araujo, Aline
Herzig, Volker
Windley, Monique J.
Dziemborowicz, Slawomir
Mobli, Mehdi
Nicholson, Graham M.
Alewood, Paul F.
King, Glenn F.
Title Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?
Journal name Antioxidants and Redox Signaling   Check publisher's open access policy
ISSN 1523-0864
1557-7716
Publication date 2013-11-26
Year available 2013
Sub-type Article (original research)
DOI 10.1089/ars.2013.5365
Open Access Status DOI
Volume 19
Issue 16
Start page 1976
End page 1980
Total pages 5
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Collection year 2014
Language eng
Abstract Vicinal disulfide bridges, in which a disulfide bond is formed between adjacent cysteine residues, constitute an unusual but expanding class of potential allosteric disulfides. Although vicinal disulfide rings (VDRs) are relatively uncommon, they have proven to be functionally critical in almost all proteins in which they have been discovered. However, it has proved difficult to test whether these sterically constrained disulfides participate in functionally important redox transformations. We demonstrate that chemical replacement of VDRs with dicarba or diselenide bridges can be used to assess whether VDRs function as allosteric disulfides. Our approach leads to the hypothesis that not all VDRs participate in functionally important redox reactions.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
Centre for Advanced Imaging Publications
 
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Created: Fri, 10 May 2013, 09:25:42 EST by Susan Allen on behalf of Institute for Molecular Bioscience