Human placental sulfate transporter mRNA profiling from term pregnancies identifies abundant SLC13A4 in syncytiotrophoblasts and SLC26A2 in cytotrophoblasts

Simmons, D. G., Rakoczy, J., Jefferis, J., Lourie, R., McIntyre, H. D. and Dawson, P. A. (2013) Human placental sulfate transporter mRNA profiling from term pregnancies identifies abundant SLC13A4 in syncytiotrophoblasts and SLC26A2 in cytotrophoblasts. Placenta, 34 4: 381-384. doi:10.1016/j.placenta.2013.01.017


Author Simmons, D. G.
Rakoczy, J.
Jefferis, J.
Lourie, R.
McIntyre, H. D.
Dawson, P. A.
Title Human placental sulfate transporter mRNA profiling from term pregnancies identifies abundant SLC13A4 in syncytiotrophoblasts and SLC26A2 in cytotrophoblasts
Formatted title
Human placental sulfate transporter mRNA profiling from term pregnancies identifies abundant SLC13A4 in syncytiotrophoblasts and SLC26A2 in cytotrophoblasts
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
1532-3102
Publication date 2013-04
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.placenta.2013.01.017
Open Access Status
Volume 34
Issue 4
Start page 381
End page 384
Total pages 4
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Sulfate is an important nutrient for fetal growth and development. The fetus has no mechanism for producing its own sulfate and is therefore totally reliant on sulfate from the maternal circulation via placental sulfate transport. To build a model of directional sulfate transport in the placenta, we investigated the relative abundance of the 10 known sulfate transporter mRNAs in human placenta from uncomplicated term pregnancies. SLC13A4 and SLC26A2 were the most abundant sulfate transporter mRNAs, which localized to syncytiotrophoblast and cytotrophoblast cells, respectively. These findings indicate important physiological roles for SLC13A4 and SLC26A2 in human placental sulfate transport.
Keyword Sulfate
Placental transport
Syncytiotrophoblast
Pregnancy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under "Short Communications"

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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