The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain

Cui, X., Pelekanos, M., Liu, P-Y, Burne, T. H. J., McGrath, J. J. and Eyles, D. W. (2013) The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience, 236 77-87. doi:10.1016/j.neuroscience.2013.01.035


Author Cui, X.
Pelekanos, M.
Liu, P-Y
Burne, T. H. J.
McGrath, J. J.
Eyles, D. W.
Title The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain
Journal name Neuroscience   Check publisher's open access policy
ISSN 0306-4522
1873-7544
Publication date 2013-04-16
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.neuroscience.2013.01.035
Open Access Status
Volume 236
Start page 77
End page 87
Total pages 11
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Collection year 2014
Language eng
Abstract There is growing evidence that vitaminDis a neuroactive steroid capable of regulating multiple pathways important for both brain development and mature brain function. In particular, there is evidence from rodent models that prenatal vitamin D deficiency alters the development of dopaminergic pathways and this disruption is associatedwith altered behavior and neurochemistry in the adult brain. Although the presence of the vitamin D receptor (VDR) has been noted in the human substantia nigra, there is a lack of direct evidence showing that VDR is present in dopaminergic cells. Here we confirm that the VDR is present in the nucleus of tyrosine hydroxylase (TH)-positive neurons in both the human and rat substantia nigra, and it emerges early in development in the rat, between embryonic day 12 (E12) and E15. Consistent evidence based on immunohistochemistry, real-time PCR and westernblotconfirmeda patternof increasingVDRexpression in the rat midbrain until weaning. The nuclear expression of VDR in TH-positive neurons during critical periods of brain development suggests that alterations in early life vitamin D statusmay influencethe orderlydevelopment ofdopaminergic neurons.
Keyword Vitamin D receptor
Brain development
Substantia nigra
Rat
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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