Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis

van Schinkel, Linda D., Auger, Dominique, van Elderen, Saskia G. C., Marsan, Nina Ajmone, Delgado, Victoria, Lamb, Hildo J., Ng, Arnold C. T., Smit, Johannes W. A., Bax. Jeroen J., Westenber, Jos J. M. and de Roos, Albert (2013) Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis. International Journal of Cardiovascular Imaging, 29 3: 633-641. doi:10.1007/s10554-012-0125-2

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Author van Schinkel, Linda D.
Auger, Dominique
van Elderen, Saskia G. C.
Marsan, Nina Ajmone
Delgado, Victoria
Lamb, Hildo J.
Ng, Arnold C. T.
Smit, Johannes W. A.
Bax. Jeroen J.
Westenber, Jos J. M.
de Roos, Albert
Title Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis
Journal name International Journal of Cardiovascular Imaging   Check publisher's open access policy
ISSN 1569-5794
1875-8312
Publication date 2013-03
Year available 2012
Sub-type Article (original research)
DOI 10.1007/s10554-012-0125-2
Open Access Status
Volume 29
Issue 3
Start page 633
End page 641
Total pages 9
Place of publication Dordrecht, The Netherlands
Publisher Springer
Collection year 2013
Language eng
Formatted abstract
Diabetes mellitus type 1 (DM1) is associated with aortic stiffening and left ventricular (LV) diastolic dysfunction, however the relationship between aortic stiffness and LV diastolic dysfunction in DM1 patients is still largely unknown. The purpose of this study was to evaluate whether an increased aortic stiffness, expressed by increased aortic pulse wave velocity (PWV), is associated with subclinical LV diastolic dysfunction and decreased left atrial (LA) compliance as assessed with speckle tracking strain analysis in patients with DM1. Aortic PWV was assessed with cardiovascular magnetic resonance in 41 DM1 patients. Patients underwent echocardiography for assessment of conventional LV diastolic function indices and LV and LA longitudinal strain and strain rate (SR) assessed with speckle tracking strain analysis. LV SR during the isovolumic relaxation period (SRIVR) and LA strain were recorded and the E-wave velocity to SRIVR velocity ratio (E/SRIVR) was calculated. Independent samples t test and multivariate linear regression analyses were used for statistical analyses. Aortic PWV significantly correlated with SRIVR (β = -0.71, p < 0.001), E/SRIVR (β = 0.61, p = 0.002) and LA strain (β = -0.47, p = 0.014), but not with conventional echocardiographic markers of diastolic function (all p > 0.10). In DM1 patients, aortic stiffness is inversely associated with sensitive markers of LV diastolic function and decrease in LA compliance as measured with echocardiographic speckle tracking strain analysis.
Keyword Aortic Stiffness
Cardiac diastolic function
Cardiovascular magnetic resonance imaging
Diabetes mellitus type 1
Echocardiography
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
Centre for Advanced Imaging Publications
 
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Created: Tue, 30 Apr 2013, 11:05:15 EST by Dr Chin Tse Arnold Ng on behalf of Medicine - Princess Alexandra Hospital