Analyses of pig genomes provide insight into porcine demography and evolution

Groenen, Martien A. M., Archibald, Alan L., Uenishi, Hirohide, Tuggle, Christopher K., Takeuchi, Yasuhiro, Rothschild, Max F., Rogel-Gaillard, Claire, Park, Chankyu, Milan, Denis, Megens, Hendrik-Jan, Li, Shengting, Larkin, Denis M., Kim, Heebal, Frantz, Laurent A. F., Caccamo, Mario, Ahn, Hyeonju, Aken, Bronwen L., Anselmo, Anna, Anthon, Christian, Auvil, Loretta, Badaoui, Bouabid, Beattie, Craig W., Bendixen, Christian, Berman, Daniel, Blecha, Frank, Blomberg, Jonas, Bolund, Lars, Bosse, Mirte, Botti, Sara, Zhan Bujie, Bystrom, Megan, Capitanu, Boris, Carvalho-Silva, Denise, Chardon, Patrick, Chen, Celine, Cheng, Ryan, Choi, Sang-Haeng, Chow, William, Clark, Richard C., Clee, Christopher, Crooijmans, Richard P. M. A., Dawson, Harry D., Dehais, Patrice, De Sapio, Fioravante, Dibbits, Bert, Drou, Nizar, Du, Zhi-Qiang, Eversole, Kellye, Fadista, Joao, Fairley, Susan, Faraut, Thomas, Faulkner, Geoffrey J., Fowler, Katie E., Fredholm, Merete, Fritz, Eric, Gilbert, James G. R., Giuffra, Elisabetta, Gorodkin, Jan, Griffin, Darren K., Harrow, Jennifer L., Hayward, Alexander, Howe, Kerstin, Hu, Zhi-Liang, Humphray, Sean J., Hunt, Toby, Hornshoj, Henrik, Jeon, Jin-Tae, Jern, Patric, Jones, Matthew, Jurka, Jerzy, Kanamori, Hiroyuki, Kapetanovic, Ronan, Kim, Jaebum, Kim, Jae-Hwan, Kim, Kyu-Won, Kim, Tae-Hun, Larson, Greger, Lee, Kyooyeol, Lee, Kyung-Tai, Leggett, Richard, Lewin, Harris A., Li, Yingrui, Liu, Wansheng, Loveland, Jane E., Lu, Yao, Lunney, Joan K., Ma, Jian, Madsen, Ole, Mann, Katherine, Matthews, Lucy, McLaren, Stuart, Morozumi, Takeya, Murtaugh, Michael P., Narayan, Jitendra, Dinh Truong Nguyen, Ni, Peixiang, Oh, Song-Jung, Onteru, Suneel, Panitz, Frank, Park, Eung-Woo, Park, Hong-Seog, Pascal, Geraldine, Paudel, Yogesh, Perez-Enciso, Miguel, Ramirez-Gonzalez, Ricardo, Reecy, James M., Rodriguez-Zas, Sandra, Rohrer, Gary A., Rund, Lauretta, Sang, Yongming, Schachtschneider, Kyle, Schraiber, Joshua G., Schwartz, John, Scobie, Linda, Scott, Carol, Searle, Stephen, Servin, Bertrand, Southey, Bruce R., Sperber, Goran, Stadler, Peter, Sweedler, Jonathan V., Tafer, Hakim, Thomsen, Bo, Wali, Rashmi, Wang, Jian, Wang, Jun, White, Simon, Xu, Xun, Yerle, Martine, Zhang, Guojie, Zhang, Jianguo, Zhang, Jie, Zhao, Shuhong, Rogers, Jane, Churcher, Carol and Schook, Lawrence B. (2012) Analyses of pig genomes provide insight into porcine demography and evolution. Nature, 491 7424: 393-398. doi:10.1038/nature11622


Author Groenen, Martien A. M.
Archibald, Alan L.
Uenishi, Hirohide
Tuggle, Christopher K.
Takeuchi, Yasuhiro
Rothschild, Max F.
Rogel-Gaillard, Claire
Park, Chankyu
Milan, Denis
Megens, Hendrik-Jan
Li, Shengting
Larkin, Denis M.
Kim, Heebal
Frantz, Laurent A. F.
Caccamo, Mario
Ahn, Hyeonju
Aken, Bronwen L.
Anselmo, Anna
Anthon, Christian
Auvil, Loretta
Badaoui, Bouabid
Beattie, Craig W.
Bendixen, Christian
Berman, Daniel
Blecha, Frank
Blomberg, Jonas
Bolund, Lars
Bosse, Mirte
Botti, Sara
Zhan Bujie
Bystrom, Megan
Capitanu, Boris
Carvalho-Silva, Denise
Chardon, Patrick
Chen, Celine
Cheng, Ryan
Choi, Sang-Haeng
Chow, William
Clark, Richard C.
Clee, Christopher
Crooijmans, Richard P. M. A.
Dawson, Harry D.
Dehais, Patrice
De Sapio, Fioravante
Dibbits, Bert
Drou, Nizar
Du, Zhi-Qiang
Eversole, Kellye
Fadista, Joao
Fairley, Susan
Faraut, Thomas
Faulkner, Geoffrey J.
Fowler, Katie E.
Fredholm, Merete
Fritz, Eric
Gilbert, James G. R.
Giuffra, Elisabetta
Gorodkin, Jan
Griffin, Darren K.
Harrow, Jennifer L.
Hayward, Alexander
Howe, Kerstin
Hu, Zhi-Liang
Humphray, Sean J.
Hunt, Toby
Hornshoj, Henrik
Jeon, Jin-Tae
Jern, Patric
Jones, Matthew
Jurka, Jerzy
Kanamori, Hiroyuki
Kapetanovic, Ronan
Kim, Jaebum
Kim, Jae-Hwan
Kim, Kyu-Won
Kim, Tae-Hun
Larson, Greger
Lee, Kyooyeol
Lee, Kyung-Tai
Leggett, Richard
Lewin, Harris A.
Li, Yingrui
Liu, Wansheng
Loveland, Jane E.
Lu, Yao
Lunney, Joan K.
Ma, Jian
Madsen, Ole
Mann, Katherine
Matthews, Lucy
McLaren, Stuart
Morozumi, Takeya
Murtaugh, Michael P.
Narayan, Jitendra
Dinh Truong Nguyen
Ni, Peixiang
Oh, Song-Jung
Onteru, Suneel
Panitz, Frank
Park, Eung-Woo
Park, Hong-Seog
Pascal, Geraldine
Paudel, Yogesh
Perez-Enciso, Miguel
Ramirez-Gonzalez, Ricardo
Reecy, James M.
Rodriguez-Zas, Sandra
Rohrer, Gary A.
Rund, Lauretta
Sang, Yongming
Schachtschneider, Kyle
Schraiber, Joshua G.
Schwartz, John
Scobie, Linda
Scott, Carol
Searle, Stephen
Servin, Bertrand
Southey, Bruce R.
Sperber, Goran
Stadler, Peter
Sweedler, Jonathan V.
Tafer, Hakim
Thomsen, Bo
Wali, Rashmi
Wang, Jian
Wang, Jun
White, Simon
Xu, Xun
Yerle, Martine
Zhang, Guojie
Zhang, Jianguo
Zhang, Jie
Zhao, Shuhong
Rogers, Jane
Churcher, Carol
Schook, Lawrence B.
Total Author Count Override 136
Title Analyses of pig genomes provide insight into porcine demography and evolution
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 2012-11
Year available 2012
Sub-type Article (original research)
DOI 10.1038/nature11622
Volume 491
Issue 7424
Start page 393
End page 398
Total pages 6
Place of publication Nature Publishing Group
Publisher London, United Kingdom
Collection year 2013
Language eng
Formatted abstract
For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ~1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.
Keyword Sus-Scrofa
Sequence
Gene
Receptor
Locus
Variants
Complex
Taste
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 29 Apr 2013, 12:31:27 EST by Ms Ramona Hooyer on behalf of Institute for Molecular Bioscience