Premalignant lesions of the urinary bladder

Samaratunga, Hemamali, Martignoni, Guido, Egevad, Lars and Delahunt, Brett (2013) Premalignant lesions of the urinary bladder. Pathology, 45 3: 243-250. doi:10.1097/PAT.0b013e32835f6169

Author Samaratunga, Hemamali
Martignoni, Guido
Egevad, Lars
Delahunt, Brett
Title Premalignant lesions of the urinary bladder
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
Publication date 2013-04
Year available 2013
Sub-type Article (original research)
DOI 10.1097/PAT.0b013e32835f6169
Volume 45
Issue 3
Start page 243
End page 250
Total pages 8
Place of publication London, United Kingdom
Publisher Lippincott Williams & Wilkins
Collection year 2014
Language eng
Abstract Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these patients will require close followup. In addition to this some lesions may mimic carcinoma, and as a consequence, misdiagnosis could result in serious over-treatment. In this review, we discuss the clinical and histological features as well as the differential diagnosis of lesions of the bladder that have the potential to progress to cancer. Specifically, we present the features of flat, papillary and atypical urothelial hyperplasia, urothelial papilloma, urothelial dysplasia, intestinal metaplasia, keratinising squamous metaplasia, verrucous squamous hyperplasia and condyloma acuminatum and examine the molecular and clinical evidence relating to their malignant potential.
Keyword Dysplasia
Urinary bladder
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 28 Apr 2013, 00:50:44 EST by System User on behalf of Discipline of Molecular and Cellular Pathology