The development of models for the evaluation of pulmonary drug disposition

Liu, Xin, Jin, Lu, Upham, John W. and Roberts, Michael S. (2013) The development of models for the evaluation of pulmonary drug disposition. Expert Opinion On Drug Metabolism & Toxicology, 9 4: 487-505. doi:10.1517/17425255.2013.754009


Author Liu, Xin
Jin, Lu
Upham, John W.
Roberts, Michael S.
Title The development of models for the evaluation of pulmonary drug disposition
Journal name Expert Opinion On Drug Metabolism & Toxicology   Check publisher's open access policy
ISSN 1742-5255
1744-7607
Publication date 2013-04
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/17425255.2013.754009
Open Access Status
Volume 9
Issue 4
Start page 487
End page 505
Total pages 19
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2014
Language eng
Formatted abstract
Introduction: The process of drug disposition in the lung after pulmonary delivery is complex involving absorptive and non-absorptive mechanisms. The lung has also been suggested to be a trapping and metabolizing organ, especially after intravenous administration of drug. A key challenge is to define the most suitable models for the evaluation of pulmonary drug disposition.

Areas covered: This review provides an overview of the anatomy and physiology of the lung and sites of action. The authors follow this with a description of the processes associated with pulmonary disposition (deposition, absorption, distribution, metabolism, and non-absorptive clearance). The article also summarizes and compares models and techniques for the assessment of drug disposition in the lung, in terms of characteristic features, advantages and disadvantages. Finally, the authors review pharmaceutical science implications of these findings.

Expert opinion: In vivo models are preferred for studying drug deposition, absorption, disposition, and response in the lung. In vitro models may be useful in the initial screening for new compounds and in drug lead optimization. The labor-intensive isolated perfused lung models are most suitable for in-depth studies on drug pulmonary disposition for lead compounds. In the future, engineered lungs may become a more convenient means of evaluating drug disposition in the lung.
Keyword Animal models
Cell culture models
Isolated perfused lung
Pulmonary drug disposition
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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