A randomised, controlled clinical trial comparing chlorhexidine gel and low-dose fluoride toothpaste to prevent early childhood caries

Pukallus, Margaret L., Plonka, Kathryn A., Barnett, Adrian G., Walsh, Laurence J., Holcombe, Trevor F. and Seow, Kim (2013) A randomised, controlled clinical trial comparing chlorhexidine gel and low-dose fluoride toothpaste to prevent early childhood caries. International Journal of Paediatric Dentistry, 23 3: 216-224. doi:10.1111/j.1365-263X.2012.01248.x


Author Pukallus, Margaret L.
Plonka, Kathryn A.
Barnett, Adrian G.
Walsh, Laurence J.
Holcombe, Trevor F.
Seow, Kim
Title A randomised, controlled clinical trial comparing chlorhexidine gel and low-dose fluoride toothpaste to prevent early childhood caries
Journal name International Journal of Paediatric Dentistry   Check publisher's open access policy
ISSN 0960-7439
1365-263X
Publication date 2013-05
Year available 2012
Sub-type Article (original research)
DOI 10.1111/j.1365-263X.2012.01248.x
Volume 23
Issue 3
Start page 216
End page 224
Total pages 9
Place of publication West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2014
Language eng
Formatted abstract
International Journal of Paediatric Dentistry 2013; 23: 216-224 Objectives. This randomised, controlled trial compared the effectiveness of 0.12% chlorhexidine (CHX) gel and 304% fluoride toothpaste to prevent early childhood caries (ECC) in a birth cohort by 24months. Methods. The participants were randomised to receive either (i) twice daily toothbrushing with toothpaste and once daily 0.12% CHX gel (n=110) or (ii) twice daily toothbrushing with toothpaste only (study controls) (n=89). The primary outcome measured was caries incidence and the secondary outcome was percentage of children with mutans streptococci (MS). All mothers were contacted by telephone at 6, 12, and 18months. At 24months, all children were examined at a community dental clinic. Results. At 24months, the caries prevalence was 5% (3/61) in the CHX and 7% (4/58) in the controls (P=0.7). There were no differences in percentages of MS-positive children between the CHX and control groups (54%vs 53%). Only 20% applied the CHX gel once daily and 80% less than once daily. Conclusions. Toothbrushing using 304% fluoride toothpaste with or without the application of chlorhexidine gel (0.12%) reduces ECC from 23% found in the general community to 5-7%. The lack of effect with chlorhexidine is likely to be due to low compliance.
Keyword Mutans Streptococci Infection
Dental Caries
Preschool Children
Efficacy
Varnish
Old
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Dentistry Publications
 
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