Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease

Doecke, James D., Simms, Lisa A., Zhao, Zhen Zhen, Huang, Ning, Hanigan, Katherine, Krishnaprasad, Krupa, Roberts, Rebecca L., Andrews, Jane M., Mahy, Gillian, Bampton, Peter, Lewindon, Peter, Florin, Timothy, Lawrance, Ian C., Gearry, Richard B., Montgomery, Grant W. and Radford-Smith, Graham L. (2013) Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease. Inflammatory Bowel Diseases, 19 2: 240-245. doi:10.1097/MIB.0b013e3182810041


Author Doecke, James D.
Simms, Lisa A.
Zhao, Zhen Zhen
Huang, Ning
Hanigan, Katherine
Krishnaprasad, Krupa
Roberts, Rebecca L.
Andrews, Jane M.
Mahy, Gillian
Bampton, Peter
Lewindon, Peter
Florin, Timothy
Lawrance, Ian C.
Gearry, Richard B.
Montgomery, Grant W.
Radford-Smith, Graham L.
Title Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease
Journal name Inflammatory Bowel Diseases   Check publisher's open access policy
ISSN 1078-0998
1536-4844
Publication date 2013-02
Sub-type Article (original research)
DOI 10.1097/MIB.0b013e3182810041
Volume 19
Issue 2
Start page 240
End page 245
Total pages 6
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams & Wilkins
Collection year 2014
Language eng
Formatted abstract
Background: The etiology of ulcerative colitis (UC) and Crohn's disease (CD) involves both genetic and environmental components. Multiple UC and CD susceptibility genes have been identified through genome-wide association studies and subsequent meta-analyses. These studies have also highlighted the presence of genes common to both diseases, and shared with several other autoimmune disorders. The aim of this study was to identify single nucleotide polymorphisms (SNPs) recently identified by the International IBD Genetics Consortium (IIBDGC) demonstrating that highly significant associations with CD could also confer genetic susceptibility to UC.

Methods: Statistical modeling was performed on 29 CD-associated SNPs. The study comprised of 1652 UC cases from the Australia and New Zealand IBD Consortium and 2363 Australian population-based controls.

Results: After adjustment for multiple comparisons, only one SNP, rs3024505, was significantly associated with UC (P = 0.001). Independent chi-square analyses identified odds ratios of 2.22 (1.48–3.37) for the rare homozygous genotype, and 1.20 (1.06–1.35) for the minor allele. Five other SNPs demonstrated moderate to weak associations with UC.

Conclusions: Of the 29 SNPs conferring high genetic susceptibility to CD, 28 were not associated with UC, thus indicating that for this SNP set there is a low level of overlap between the two major forms of IBD. Only one SNP, rs3024505 (Chr 1q32.1, upstream of IL10), was associated with susceptibility to UC. The identification of this SNP replicates a finding from Franke et al (2008), where the rs3024505 SNP was strongly associated with UC across multiple European populations.
Keyword Crohn's disease
Ulcerative colitis
Single nucleotide polymorphism
Genome-wide association
Inflammatory-bowel-disease
Risk loci
Expression
Pathogenesis
Population
Autophagy
ATG16L1
Variant
Number
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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