Melanocytic naevi and basal cell carcinoma: is there an association?

Richmond-Sinclair, N. M., van der Pols, J. C. and Green, A. C. (2012) Melanocytic naevi and basal cell carcinoma: is there an association?. Journal of the European Academy of Dermatology and Venereology, 26 9: 1092-1096. doi:10.1111/j.1468-3083.2011.04213.x

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Author Richmond-Sinclair, N. M.
van der Pols, J. C.
Green, A. C.
Title Melanocytic naevi and basal cell carcinoma: is there an association?
Journal name Journal of the European Academy of Dermatology and Venereology   Check publisher's open access policy
ISSN 0926-9959
1468-3083
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1111/j.1468-3083.2011.04213.x
Volume 26
Issue 9
Start page 1092
End page 1096
Total pages 5
Place of publication West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2013
Language eng
Formatted abstract
Background  Melanoma and basal cell carcinoma (BCC) affect similar body sites and share a complex relationship with sun exposure.

Objective  To establish the existence and magnitude of association between melanocytic naevi, the strongest predictors of melanoma, and BCC to give possible insights into shared pathways of solar ultraviolet tumourigenesis.

Methods 
In a community-based longitudinal Australian study, detailed information was collected about sun sensitivity, and dermatologists assessed skin colour and counted naevi on the forearms (1986) and back (1992). The BCC frequency and sites were prospectively monitored until 2007. Multivariate logistic regression was used to assess the association of naevi on the forearms or on the back with the development of BCC, adjusting for other risk factors.

Results  Of 1621 study participants in 1992, 1339 (average age 49) had complete follow-up and 401 (30%) of these had 1202 histologically confirmed BCCs until 2007. After adjustment for age, gender, skin colour, naevi on the back and sun exposure, overall BCC risk increased significantly in those with forearm naevi (odds ratio: 1.5; 95% confidence intervals: 1.1–1.9). Risk of BCC specifically on the back was doubled in those with many (11 or more) forearm naevi compared with no forearm naevi (odds ratio: 2.4; 95% confidence interval: 1.1–4.8). Naevi on the back were not associated with subsequent basal cell carcinoma.

Conclusions
  High naevus prevalence on the arms is associated with future BCC development.
Keyword Risk-factors
Skin-cancer
Cutaneous melanoma
Sun exposure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
 
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