Early events in innate immunity in the recognition of microbial pathogens

Kapetanovic, Ronan and Cavaillon, Jean-Marc (2007) Early events in innate immunity in the recognition of microbial pathogens. Expert Opinion On Biological Therapy, 7 6: 907-918. doi:10.1517/14712598.7.6.907


Author Kapetanovic, Ronan
Cavaillon, Jean-Marc
Title Early events in innate immunity in the recognition of microbial pathogens
Journal name Expert Opinion On Biological Therapy   Check publisher's open access policy
ISSN 1471-2598
1744-7682
Publication date 2007-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/14712598.7.6.907
Volume 7
Issue 6
Start page 907
End page 918
Total pages 12
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Abstract Innate immunity is characterised by a rapid action of host effector molecules and leukocytes aimed at limiting the multiplication of invading microbial organisms and destroying them. The recognition and destruction of microorganisms involves humoral factors (e.g., the complement system and natural antibodies) and different cell types (e.g., phagocytic cells, mast cells, natural killer cells). Microbial detection by cells involves germ line-encoded pattern-recognition receptors such as Toll-like receptors and nucleotide-binding oligomerization domain-like receptors. Cellular activation by pathogens leads to the release of antimicrobial peptides (e.g., defensins and peptidoglycan recognition proteins) and cytokines that orchestrate the anti-infectious response. Cytokines enhance phagocytosis and leukocyte microbicidal activity, allow cellular recruitment into the infectious focus, boost hematopoiesis, induce fever and lead to the production of acute phase proteins.
Keyword Chemokines
Macrophages
Pathogen-associated molecular patterns
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
 
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