Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Morris, Andrew P., Voight, Benjamin F., Teslovich, Tanya M., Ferreira, Teresa, Segre, Ayellet V., Steinthorsdottir, Valgerdur, Strawbridge, Rona J., Khan, Hassan, Grallert, Harald, Mahajan, Anubha, Prokopenko, Inga, Kang, Hyun Min, Dina, Christian, Esko, Tonu, Fraser, Ross M., Kanoni, Stavroula, Kumar, Ashish, Lagou, Vasiliki, Langenberg, Claudia, Luan, Jian'an, Lindgren, Cecilia M., Mueller-Nurasyid, Martina, Pechlivanis, Sonali, Rayner, N. William, Scott, Laura J., Wiltshire, Steven, Yengo, Loic, Kinnunen, Leena, Rossin, Elizabeth J., Raychaudhuri, Soumya, Johnson, Andrew D., Dimas, Antigone S., Loos, Ruth J. F., Vedantam, Sailaja, Chen, Han, Florez, Jose C., Fox, Caroline, Liu, Ching-Ti, Rybin, Denis, Couper, David J., Kao, Wen Hong L., Li, Man, Cornelis, Marilyn C., Kraft, Peter, Sun, Qi, van Dam, Rob M., Stringham, Heather M., Chines, Peter S., Fischer, Krista, Fontanillas, Pierre, Holmen, Oddgeir L., Hunt, Sarah E., Jackson, Anne U., Kong, Augustine, Lawrence, Robert, Meyer, Julia, Perry, John R. B., Platou, Carl G. P., Potter, Simon, Rehnberg, Emil, Robertson, Neil, Sivapalaratnam, Suthesh, Stancakova, Alena, Stirrups, Kathleen, Thorleifsson, Gudmar, Tikkanen, Emmi, Wood, Andrew R., Almgren, Peter, Atalay, Mustafa, Benediktsson, Rafn, Bonnycastle, Lori L., Burtt, Noel, Carey, Jason, Charpentier, Guillaume, Crenshaw, Andrew T., Doney, Alex S. F., Dorkhan, Mozhgan, Edkins, Sarah, Emilsson, Valur, Eury, Elodie, Forsen, Tom, Gertow, Karl, Gigante, Bruna, Grant, George B., Groves, Christopher J., Guiducci, Candace, Herder, Christian, Hreidarsson, Astradur B., Hui, Jennie, James, Alan, Jonsson, Anna, Rathmann, Wolfgang, Klopp, Norman, Kravic, Jasmina, Krjutskov, Kaarel, Langford, Cordelia, Leander, Karin, Lindholm, Eero, Lobbens, Stephane, Mannisto, Satu, Mirza, Ghazala, Muehleisen, Thomas W., Musk, Bill, Parkin, Melissa, Rallidis, Loukianos, Saramies, Jouko, Sennblad, Bengt, Shah, Sonia, Sigurdsson, Gunnar, Silveira, Angela, Steinbach, Gerald, Thorand, Barbara, Trakalo, Joseph, Veglia, Fabrizio, Wennauer, Roman, Winckler, Wendy, Zabaneh, Delilah, Campbell, Harry, van Duijn, Cornelia, Uitterlinden, Andre G., Hofman, Albert, Sijbrands, Eric, Abecasis, Goncalo R., Owen, Katharine R., Zeggini, Eleftheria, Trip, Mieke D., Forouhi, Nita G., Syvanen, Ann-Christine, Eriksson, Johan G., Peltonen, Leena, Noethen, Markus M., Balkau, Beverley, Palmer, Colin N. A., Lyssenko, Valeriya, Tuomi, Tiinamaija, Isomaa, Bo, Hunter, David J., Qi, Lu, Wellcome Trust Case Control Consortium, Brown, Matthew A., Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Asian Genetic Epidemiology Network–Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Shuldiner, Alan R., Roden, Michael, Barroso, Ines, Wilsgaard, Tom, Beilby, John, Hovingh, Kees, Price, Jackie F., Wilson, James F., Rauramaa, Rainer, Lakka, Timo A., Lind, Lars, Njolstad, Inger, Pedersen, Nancy L., Dedoussis, George, Khaw, Kay-Tee, Wareham, Nicholas J., Keinanen-Kiukaanniemi, Sirkka M., Saaristo, Timo E., Korpi-Hyovalti, Eeva, Saltevo, Juha, Laakso, Markku, Kuusisto, Johanna, Metspalu, Andres, Collins, Francis S., Mohlke, Karen L., Bergman, Richard N., Tuomilehto, Jaakko, Boehm, Bernhard O., Gieger, Christian, Hveem, Kristian, Cauchi, Stephane, Froguel, Philippe, Baldassarre, Damiano, Tremoli, Elena, Humphries, Steve E., Saleheen, Danish, Danesh, John, Ingelsson, Erik, Ripatti, Samuli, Salomaa, Veikko, Erbel, Raimund, Joeckel, Karl-Heinz, Moebus, Susanne, Peters, Annette, Hamsten, Anders, Illig, Thomas, de Faire, Ulf, Morris, Andrew D., Donnelly, Peter J., Frayling, Timothy M., Hattersley, Andrew T., Boerwinkle, Eric, Melander, Olle, Kathiresan, Sekar, Nilsson, Peter M., Deloukas, Panos, Thorsteinsdottir, Unnur, Groop, Leif C., Stefansson, Kari, Hu, Frank, Pankow, James S., Dupuis, Josee, Meigs, James B., Altshuler, David, Boehnke, Michael, McCarthy, Mark I. and DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium (2012) Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44 9: 981-990. doi:10.1038/ng.2383


Author Morris, Andrew P.
Voight, Benjamin F.
Teslovich, Tanya M.
Ferreira, Teresa
Segre, Ayellet V.
Steinthorsdottir, Valgerdur
Strawbridge, Rona J.
Khan, Hassan
Grallert, Harald
Mahajan, Anubha
Prokopenko, Inga
Kang, Hyun Min
Dina, Christian
Esko, Tonu
Fraser, Ross M.
Kanoni, Stavroula
Kumar, Ashish
Lagou, Vasiliki
Langenberg, Claudia
Luan, Jian'an
Lindgren, Cecilia M.
Mueller-Nurasyid, Martina
Pechlivanis, Sonali
Rayner, N. William
Scott, Laura J.
Wiltshire, Steven
Yengo, Loic
Kinnunen, Leena
Rossin, Elizabeth J.
Raychaudhuri, Soumya
Johnson, Andrew D.
Dimas, Antigone S.
Loos, Ruth J. F.
Vedantam, Sailaja
Chen, Han
Florez, Jose C.
Fox, Caroline
Liu, Ching-Ti
Rybin, Denis
Couper, David J.
Kao, Wen Hong L.
Li, Man
Cornelis, Marilyn C.
Kraft, Peter
Sun, Qi
van Dam, Rob M.
Stringham, Heather M.
Chines, Peter S.
Fischer, Krista
Fontanillas, Pierre
Holmen, Oddgeir L.
Hunt, Sarah E.
Jackson, Anne U.
Kong, Augustine
Lawrence, Robert
Meyer, Julia
Perry, John R. B.
Platou, Carl G. P.
Potter, Simon
Rehnberg, Emil
Robertson, Neil
Sivapalaratnam, Suthesh
Stancakova, Alena
Stirrups, Kathleen
Thorleifsson, Gudmar
Tikkanen, Emmi
Wood, Andrew R.
Almgren, Peter
Atalay, Mustafa
Benediktsson, Rafn
Bonnycastle, Lori L.
Burtt, Noel
Carey, Jason
Charpentier, Guillaume
Crenshaw, Andrew T.
Doney, Alex S. F.
Dorkhan, Mozhgan
Edkins, Sarah
Emilsson, Valur
Eury, Elodie
Forsen, Tom
Gertow, Karl
Gigante, Bruna
Grant, George B.
Groves, Christopher J.
Guiducci, Candace
Herder, Christian
Hreidarsson, Astradur B.
Hui, Jennie
James, Alan
Jonsson, Anna
Rathmann, Wolfgang
Klopp, Norman
Kravic, Jasmina
Krjutskov, Kaarel
Langford, Cordelia
Leander, Karin
Lindholm, Eero
Lobbens, Stephane
Mannisto, Satu
Mirza, Ghazala
Muehleisen, Thomas W.
Musk, Bill
Parkin, Melissa
Rallidis, Loukianos
Saramies, Jouko
Sennblad, Bengt
Shah, Sonia
Sigurdsson, Gunnar
Silveira, Angela
Steinbach, Gerald
Thorand, Barbara
Trakalo, Joseph
Veglia, Fabrizio
Wennauer, Roman
Winckler, Wendy
Zabaneh, Delilah
Campbell, Harry
van Duijn, Cornelia
Uitterlinden, Andre G.
Hofman, Albert
Sijbrands, Eric
Abecasis, Goncalo R.
Owen, Katharine R.
Zeggini, Eleftheria
Trip, Mieke D.
Forouhi, Nita G.
Syvanen, Ann-Christine
Eriksson, Johan G.
Peltonen, Leena
Noethen, Markus M.
Balkau, Beverley
Palmer, Colin N. A.
Lyssenko, Valeriya
Tuomi, Tiinamaija
Isomaa, Bo
Hunter, David J.
Qi, Lu
Wellcome Trust Case Control Consortium
Brown, Matthew A.
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators
Genetic Investigation of ANthropometric Traits (GIANT) Consortium
Asian Genetic Epidemiology Network–Type 2 Diabetes (AGEN-T2D) Consortium
South Asian Type 2 Diabetes (SAT2D) Consortium
Shuldiner, Alan R.
Roden, Michael
Barroso, Ines
Wilsgaard, Tom
Beilby, John
Hovingh, Kees
Price, Jackie F.
Wilson, James F.
Rauramaa, Rainer
Lakka, Timo A.
Lind, Lars
Njolstad, Inger
Pedersen, Nancy L.
Dedoussis, George
Khaw, Kay-Tee
Wareham, Nicholas J.
Keinanen-Kiukaanniemi, Sirkka M.
Saaristo, Timo E.
Korpi-Hyovalti, Eeva
Saltevo, Juha
Laakso, Markku
Kuusisto, Johanna
Metspalu, Andres
Collins, Francis S.
Mohlke, Karen L.
Bergman, Richard N.
Tuomilehto, Jaakko
Boehm, Bernhard O.
Gieger, Christian
Hveem, Kristian
Cauchi, Stephane
Froguel, Philippe
Baldassarre, Damiano
Tremoli, Elena
Humphries, Steve E.
Saleheen, Danish
Danesh, John
Ingelsson, Erik
Ripatti, Samuli
Salomaa, Veikko
Erbel, Raimund
Joeckel, Karl-Heinz
Moebus, Susanne
Peters, Annette
Hamsten, Anders
Illig, Thomas
de Faire, Ulf
Morris, Andrew D.
Donnelly, Peter J.
Frayling, Timothy M.
Hattersley, Andrew T.
Boerwinkle, Eric
Melander, Olle
Kathiresan, Sekar
Nilsson, Peter M.
Deloukas, Panos
Thorsteinsdottir, Unnur
Groop, Leif C.
Stefansson, Kari
Hu, Frank
Pankow, James S.
Dupuis, Josee
Meigs, James B.
Altshuler, David
Boehnke, Michael
McCarthy, Mark I.
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
Total Author Count Override 1042
Title Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1038/ng.2383
Volume 44
Issue 9
Start page 981
End page 990
Total pages 10
Place of publication New York, NY United States
Publisher Nature Publishing Group
Collection year 2013
Language eng
Formatted abstract
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.
Keyword Genome wide association
Susceptibility Loci
Insulin-Resistance
Common Variants
Metaanalysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
UQ Diamantina Institute Publications
 
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Created: Mon, 15 Apr 2013, 12:05:00 EST by Kylie Hengst on behalf of UQ Diamantina Institute