Prognostic implications of left ventricular dyssynchrony early after non-ST elevation myocardial infarction without congestive heart failure

Ng, Arnold C. T., Tran, Da T., Allman, Christine, Vidaic, Jane and Leung, Dominic Y. (2010) Prognostic implications of left ventricular dyssynchrony early after non-ST elevation myocardial infarction without congestive heart failure. European Heart Journal, 31 3: 298-308. doi:10.1093/eurheartj/ehp488


Author Ng, Arnold C. T.
Tran, Da T.
Allman, Christine
Vidaic, Jane
Leung, Dominic Y.
Title Prognostic implications of left ventricular dyssynchrony early after non-ST elevation myocardial infarction without congestive heart failure
Journal name European Heart Journal   Check publisher's open access policy
ISSN 0195-668X
1522-9645
Publication date 2010-02
Sub-type Article (original research)
DOI 10.1093/eurheartj/ehp488
Volume 31
Issue 3
Start page 298
End page 308
Total pages 11
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Aims To determine independent predictors of left ventricular (LV) dyssynchrony after non-ST elevation myocardial infarction (NSTEMI) and prognostic value of combining dyssynchrony parameters for long-term LV dysfunction.
Methods and results Left ventricular dyssynchrony assessments were performed in 100 NSTEMI patients followed-up for 1 year using a composite dyssynchrony score. Early LV dyssynchrony was independently predicted by the presence of significant proximal left circumflex artery (LCx) stenosis and global systolic dysfunction. Left ventricular end-diastolic volume index decreased with time and was independently determined by a lower number of diseased vessels and the absence of early dyssynchrony. Left ventricular end-systolic volume index decreased with time and was independently determined by the absence of early dyssynchrony, lower number of diseased vessels, and revascularization. Left ventricular ejection fraction increased with time and was independently determined by the absence of early dyssynchrony, lower number of diseased vessels, and revascularization. The composite dyssynchrony score was an independent determinant of a persistently dilated LV and low LVEF at follow-up.
Conclusion After NSTEMI, proximal LCx stenosis and impaired LV function independently predicted LV dyssynchrony. The composite dyssynchrony score had prognostic value and identified patients with persistently dilated and impaired LV on follow-up.
Keyword Myocardial infarction
Echocardiography
Dyssynchrony
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Medicine Publications
Centre for Advanced Imaging Publications
 
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Created: Mon, 15 Apr 2013, 00:05:36 EST by Dr Chin Tse Arnold Ng on behalf of Centre for Advanced Imaging