Echocardiography and non-invasive imaging in cardiac resynchronization therapy

Delgado, V., Mooyaart, E. A. Q., Ng, A. C. T., Auger, D., Bertini, M., van Bommel, R. J., Yiu, K. H., Ewe, S. H., Witkowski, T. G., Marsan, N. Ajmone, Schuijf, J. D., van der Wall, E. E., Schalij, M. J. and Bax, J. J. (2010) Echocardiography and non-invasive imaging in cardiac resynchronization therapy. Minerva Cardioangiologica, 58 3: 313-332.

Author Delgado, V.
Mooyaart, E. A. Q.
Ng, A. C. T.
Auger, D.
Bertini, M.
van Bommel, R. J.
Yiu, K. H.
Ewe, S. H.
Witkowski, T. G.
Marsan, N. Ajmone
Schuijf, J. D.
van der Wall, E. E.
Schalij, M. J.
Bax, J. J.
Title Echocardiography and non-invasive imaging in cardiac resynchronization therapy
Journal name Minerva Cardioangiologica   Check publisher's open access policy
ISSN 0026-4725
1827-1618
Publication date 2010-06
Sub-type Critical review of research, literature review, critical commentary
Volume 58
Issue 3
Start page 313
End page 332
Total pages 20
Place of publication Turin, Italy
Publisher Edizioni Minerva Medica
Language eng
Abstract The beneficial effects of cardiac resynchronization therapy (CRT) on morbidity and mortality in advanced heart failure patients have been extensively demonstrated. However, previous single- and multicenter studies demonstrated that approximately 30-40% of CRT patients do not show significant clinical improvement or LV reverse remodeling despite fulfilling current inclusion criteria. In search of novel indices that may help to improve the selection of responders to CRT, non-invasive multimodality imaging has provided further insight into the mechanisms underlying CRT response. LV dyssynchrony, extent and location of myocardial scar and LV lead position have shown to be independent determinants of CRT response. An integrated evaluation of these three pathophysiological mechanisms may provide a more accurate selection of heart failure patients who will benefit from CRT and may maximize the cost-effectiveness of this therapy. The present review article provides a critical appraisal of the role of multimodality imaging in the selection of heart failure patients who are candidates for CRT with special focus on the assessment of LV mechanical dyssynchrony, LV myocardial scar tissue extent and LV lead position.
Keyword Cardiac resynchronization therapy
Diagnostic imaging
Echocardiography
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: School of Medicine Publications
Centre for Advanced Imaging Publications
 
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Created: Mon, 15 Apr 2013, 00:02:05 EST by Dr Chin Tse Arnold Ng on behalf of Centre for Advanced Imaging