Location and Severity of Aortic Valve Calcium and Implications for Aortic Regurgitation After Transcatheter Aortic Valve Implantation

Ewe, See Hooi, Ng, Arnold C. T., Schuijf, Joanne D., van der Kley, Frank, Colli, Andrea, Palmen, Meindert, de Weger, Arend, Marsan, Nina Ajmone, Holman, Eduard R., de Roos, Albert, Schalij, Martin J., Bax, Jeroen J. and Delgado, Victoria (2011) Location and Severity of Aortic Valve Calcium and Implications for Aortic Regurgitation After Transcatheter Aortic Valve Implantation. American Journal of Cardiology, 108 10: 1470-1477. doi:10.1016/j.amjcard.2011.07.007

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Author Ewe, See Hooi
Ng, Arnold C. T.
Schuijf, Joanne D.
van der Kley, Frank
Colli, Andrea
Palmen, Meindert
de Weger, Arend
Marsan, Nina Ajmone
Holman, Eduard R.
de Roos, Albert
Schalij, Martin J.
Bax, Jeroen J.
Delgado, Victoria
Title Location and Severity of Aortic Valve Calcium and Implications for Aortic Regurgitation After Transcatheter Aortic Valve Implantation
Journal name American Journal of Cardiology   Check publisher's open access policy
ISSN 0002-9149
1879-1913
Publication date 2011-11
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.amjcard.2011.07.007
Open Access Status
Volume 108
Issue 10
Start page 1470
End page 1477
Total pages 8
Place of publication Bridgewater, NJ United States
Publisher Excerpta Medica
Collection year 2011
Language eng
Formatted abstract
Location of aortic valve calcium (AVC) can be better visualized on contrast-enhanced multidetector row computed tomography. The present evaluation examined whether AVC severity and its location could influence paravalvular aortic regurgitation (AR) after transcatheter aortic valve implantation. A total of 79 patients (age 80 ± 7 years, 49% men) with preprocedural multidetector row computed tomography were included. Volumetric AVC quantification and its location were assessed. Transesophageal echocardiography was performed to assess the presence and site of AR after transcatheter aortic valve implantation. Receiver operating characteristic curves were generated to evaluate the usefulness of AVC in determining paravalvular AR at a specific site. Postprocedural AR of grade 1 or more was observed in 63 patients. In most patients (n = 56, 71%), AR was of paravalvular origin. Calcium at the aortic wall of each valve cusp had the largest area under the curve (0.93, p <0.001) in predicting paravalvular AR at the aortic wall site compared to calcium at the valvular edge or body (area under the curve 0.58 and 0.67, respectively). Calcium at the valvular commissure was better than calcium at the valvular edge (area under the curve 0.94 vs 0.71) in predicting paravavular AR originating from the corresponding commissure. In conclusion, contrast-enhanced multidetector row computed tomography can be performed to quantify AVC. Both AVC severity and its exact location are important in determining paravalvular AR after transcatheter aortic valve implantation
Keyword Society of Cardiology
Computed Tomography
Calcification
Stenosis
Echocardiography
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Sun, 14 Apr 2013, 23:53:48 EST by Dr Chin Tse Arnold Ng on behalf of Medicine - Princess Alexandra Hospital