Urinary pharmacokinetics of Queen Garnet plum anthocyanins in healthy human subjects

Netzel, M., Fanning, K., Netzel, G., Frank, T., Zabaras, D., Russell, D. and Stanley, R. (2012). Urinary pharmacokinetics of Queen Garnet plum anthocyanins in healthy human subjects. In Bhimanagouda S Patil (Ed.), Emerging Trends in Dietary Components for Preventing and Combating Disease (pp. 375-392) Washington DC, United States: ACS Publications. doi:10.1021/bk-2012-1093.ch021


Author Netzel, M.
Fanning, K.
Netzel, G.
Frank, T.
Zabaras, D.
Russell, D.
Stanley, R.
Title of chapter Urinary pharmacokinetics of Queen Garnet plum anthocyanins in healthy human subjects
Title of book Emerging Trends in Dietary Components for Preventing and Combating Disease
Place of Publication Washington DC, United States
Publisher ACS Publications
Publication Year 2012
Sub-type Research book chapter (original research)
DOI 10.1021/bk-2012-1093.ch021
Open Access Status
Series ACS Symposium Series
ISBN 9780841226647
9780841226661
ISSN 0097-6156
1947-5918
Editor Bhimanagouda S Patil
Volume number 1093
Chapter number 21
Start page 375
End page 392
Total pages 18
Total chapters 32
Collection year 2013
Language eng
Formatted Abstract/Summary
A new variety of Prunus salicina, Queen Garnet plum (QGP), was developed as a high anthocyanin, high antioxidant plum, in a Queensland, Australia, Government breeding program. In this manuscript, we are presenting for the first time data about the urinary pharmacokinetics of QGP anthocyanins and derived metabolites in healthy humans. Following consumption of 400 mL QGP juice (QGPJ; 2.49 mmol anthocyanins) by two male subjects, QGP anthocyanins (cyanidin-3-glucoside and cyanidin-3-rutinoside) were excreted mainly as methylated glycosides, glucuronides, and sulfoconjugated metabolites in urine. The cumulative excretion of anthocyanins could be fitted to a one-compartment pharmacokinetic model with instantaneous, parallel excretion of anthocyanin metabolites. The usefulness of this non-linear modeling statistical technique for characterizing the urine excretion-time profiles and estimating relevant PK parameters is demonstrated. Results from this pilot study indicate that methylation and glucuronidation are significant metabolic routes when cyanidin-based anthocyanins are consumed in QGPJ. Future studies investigating the benefits of the consumption of anthocyanin-rich Queen Garnet plums and/or derived products should therefore focus on identifying anthocyanin metabolites and include their putative colonic degradation products. This will assist in evaluating the biological relevance of these compounds to health and disease prevention.
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 14 Apr 2013, 16:34:32 EST by Michael Netzel on behalf of Qld Alliance for Agriculture and Food Innovation