Zinc oxide nanoparticle removal from wounded human skin

Raphael, Anthony P., Sundh, Daniel, Grice, Jeffrey E., Soyer, Peter H. and Prow, Tarl W. (2013) Zinc oxide nanoparticle removal from wounded human skin. Nanomedicine, 8 11: 1751-1761. doi:10.2217/NNM.12.196


Author Raphael, Anthony P.
Sundh, Daniel
Grice, Jeffrey E.
Soyer, Peter H.
Prow, Tarl W.
Title Zinc oxide nanoparticle removal from wounded human skin
Journal name Nanomedicine   Check publisher's open access policy
ISSN 1743-5889
1748-6963
Publication date 2013-11
Year available 2013
Sub-type Article (original research)
DOI 10.2217/NNM.12.196
Volume 8
Issue 11
Start page 1751
End page 1761
Total pages 11
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2014
Language eng
Formatted abstract
Aim: Nanoparticle removal from skin is relevant given the concern over topical nanoparticle toxicity. Zinc oxide nanoparticles (ZnO-NPs) are commonly used in sunscreens and their use is currently debated. This study explores the penetration and removal of ZnO-NPs from injured skin.

Materials & methods: Ex/in vivo human skin was tape-stripped and/or microneedled followed by ZnO-NP application. After 2 h, treated skin was washed three-times using soapy water. Multiphoton tomography assessed the ZnO-NP signal before and after washing.

Results: Washing once removed over 85 and 83% of ZnO-NP signal from ex vivo
intact and tape-stripped skin, respectively (p < 0.05) but only 28% (p = 0.5) was removed from puncture sites. A similar trend was found in vivo with removal of 85 and 93% of ZnO-NP signal from intact and tape-stripped skin, respectively (p < 0.05).

Conclusion: Washing is effective for the removal of ZnO-NPs from superficial layers of intact and tape-stripped skin, but not from puncture wounds.
Keyword Multiphoton tomography
Nanodermatology
Nanoparticle
Noninvasive imaging
Skin
Sunscreen
Zinc oxide
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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Created: Sun, 14 Apr 2013, 11:17:27 EST by Nicole Lin on behalf of Medicine - Princess Alexandra Hospital