Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease

Frost, S., Kanagasingam, Y., Sohrabi, H., Vignarajan, J., Bourgeat, P., Salvado, O., Villemagne, V., Rowe, C. C., Macaulay, S. Lance, Szoeke, C., Ellis, K. A., Ames, D., Masters, C. L., Rainey-Smith, S. and Martins, R. N. (2013) Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. Translational Psychiatry, 3 . doi:10.1038/tp.2012.150

Author Frost, S.
Kanagasingam, Y.
Sohrabi, H.
Vignarajan, J.
Bourgeat, P.
Salvado, O.
Villemagne, V.
Rowe, C. C.
Macaulay, S. Lance
Szoeke, C.
Ellis, K. A.
Ames, D.
Masters, C. L.
Rainey-Smith, S.
Martins, R. N.
Title Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease
Journal name Translational Psychiatry   Check publisher's open access policy
ISSN 2158-3188
Publication date 2013-02-26
Year available 2013
Sub-type Article (original research)
DOI 10.1038/tp.2012.150
Open Access Status DOI
Volume 3
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2014
Language eng
Abstract The earliest detectable change in Alzheimer’s disease (AD) is the buildup of amyloid plaque in the brain. Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET imaging and CSF amyloid are the gold standards for early AD diagnosis, there are practical limitations for population screening. AD-related pathology occurs primarily in the brain, but some of the hallmarks of the disease have also been shown to occur in other tissues, including the retina, which is more accessible for imaging. Retinal vascular changes and degeneration have previously been reported in AD using optical coherence tomography and laser Doppler techniques. This report presents results from analysis of retinal photographs from AD and healthy control participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing. This is the first study to investigate retinal blood vessel changes with respect to amyloid plaque burden in the brain. We demonstrate relationships between retinal vascular parameters, neocortical brain amyloid plaque burden and AD. A number of RVPs were found to be different in AD. Two of these RVPs, venular branching asymmetry factor and arteriolar length-to-diameter ratio, were also higher in healthy individuals with high plaque burden (P=0.01 and P=0.02 respectively, after false discovery rate adjustment). Retinal photographic analysis shows potential as an adjunct for early detection of AD or monitoring of AD-progression or response to treatments.
Keyword Alzheimer's
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article # e233

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
School of Information Technology and Electrical Engineering Publications
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