Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection

Ulett, G. C., Makrina Totsika, Kolja Schaale, Carey, A. J., Sweet, Matthew J. and Schembri, Mark A. (2013) Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection. Current Opinion in Microbiology, 16 1: 100-107. doi:10.1016/j.mib.2013.01.005

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Author Ulett, G. C.
Makrina Totsika
Kolja Schaale
Carey, A. J.
Sweet, Matthew J.
Schembri, Mark A.
Title Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection
Journal name Current Opinion in Microbiology   Check publisher's open access policy
ISSN 1369-5274
1879-0364
Publication date 2013-02-08
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.mib.2013.01.005
Open Access Status File (Author Post-print)
Volume 16
Issue 1
Start page 100
End page 107
Total pages 8
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Urinary tract infections (UTI) are among the most common infectious diseases of humans and are the most common nosocomial infections in the developed world. It is estimated that 40–50% of women and 5% of men will develop a UTI in their lifetime, and UTI accounts for more than 1 million hospitalizations and $1.6 billion in medical expenses each year in the USA. Uropathogenic Escherichia coli (UPEC) is the primary cause of UTI. This review presents an overview of recent discoveries related to the primary virulence factors of UPEC and major innate immune responses to infection of the lower urinary tract. New and emerging themes in UPEC research are discussed in the context of the interface between host and pathogen.
Keyword Bacterial colonization
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 66 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 73 times in Scopus Article | Citations
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Created: Fri, 12 Apr 2013, 15:13:54 EST by Susan Allen on behalf of Institute for Molecular Bioscience